衣康酸及其衍生物在脓毒症中的作用研究进展OA
Research progress of itaconic acid and its derivatives in sepsis
脓毒症是由感染引起的机体反应失调所导致的多器官功能障碍,具有高发病率、高死亡率及高治疗费用的特点,且缺乏有效的治疗手段,近年来对全球造成的医疗负担日趋严重,因此探索脓毒症的发生发展机制并找寻可能改善或阻止脓毒症发生发展的新型治疗药物势在必行.研究发现,衣康酸作为免疫细胞中天然存在的代谢物,具有调节炎性反应和免疫代谢等重要作用,可能是一种防治脓毒症非常有前途的药物.文章从衣康酸在脓毒症治疗和多器官功能保护方面的作用机制及疗效的研究进展进行综述,以期为脓毒症的研究和治疗提供更多思路和帮助.
Sepsis is multi-organ dysfunction due to a dysregulated response to infection.Due to the high morbidity,high mortality and high treatment costs,and the lack of effective treatment methods,the global medical burden has become in-creasingly serious in recent years,so it is imperative to explore the mechanism of the occurrence and development of sepsis and find new therapeutic drugs that may improve or prevent the occurrence and development of sepsis.Studies have found that itaconic acid,as a naturally occurring metabolite in immune cells,plays an important role in regulating inflammation and im-mune metabolism,and may be a very promising drug for the prevention and treatment of sepsis.This article reviews the re-search progress on the mechanism of action and efficacy of itaconic acid in the treatment of sepsis and the protection of multi-organ function,in order to provide more ideas and help for the research and treatment of sepsis.
南龙腾;王聪睿;侯曼;张文凯
030001 太原,山西医科大学030001 太原,山西医科大学030001 太原,山西医科大学山西医科大学第二医院重症医学科三病区
医药卫生
脓毒症多器官功能障碍综合征衣康酸器官保护炎性反应
SepsisMultiple organ dysfunction syndromeItaconic acidOrgan protectionInflammation
《疑难病杂志》 2026 (3)
380-384,5
山西省自然科学基金项目(202203021221278) Natural Science Foundation of Shanxi Province(202203021221278)
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