复方苁蓉益智胶囊治疗阿尔茨海默病的中西医研究进展OA
Research progress on Fufang Congrong Yizhi capsule in the treatment of Alzheimer's disease with traditional chinese and western medicine
阿尔茨海默病(AD)是一种以进行性认知功能障碍和记忆力减退为主要特征的神经退行性疾病,现有单靶点药物治疗效果有限.复方苁蓉益智胶囊通过多成分、多靶点干预AD病理环节,在抑制β淀粉样蛋白沉积与tau蛋白磷酸化、抗神经炎性反应、抗氧化应激与神经保护等方面发挥药理机制.本文旨在为复方苁蓉益智胶囊的深入研究和临床合理应用提供参考,并明确未来需通过大规模、长周期随机对照试验验证其长期疗效与安全性,为AD的治疗提供新思路.
Alzheimer's disease(AD)is a neurodegenerative disorder characterised primarily by progressive cognitive impairment and memory loss,with existing single-target drug treatments showing limited efficacy.Fufang Congrong Yizhi cap-sule exerts its pharmacological mechanisms through multi-component,multi-target interventions in AD pathological processes,including inhibition of β-amyloid deposition and tau protein phosphorylation,anti-neuroinflammation,antioxidative stress,and neuroprotection.This article aims to provide a reference for in-depth research and rational clinical application of Fufang Congrong Yizhi capsule,and to clarify the need for future large-scale,long-term randomised controlled trials to verify its long-term efficacy and safety,offering new approaches for AD treatment.
胡鹏;陈东晓;郭楠楠
100102 北京,中国中医科学院望京医院针灸神经内科100102 北京,中国中医科学院望京医院针灸神经内科100102 北京,中国中医科学院望京医院针灸神经内科
医药卫生
复方苁蓉益智胶囊阿尔茨海默病中西医结合药理机制循证医学
Fufang Congrong Yizhi capsuleAlzheimer's diseaseIntegrative medicinePharmacological mechanismEvidence-based medicine
《疑难病杂志》 2026 (3)
364-368,5
首都卫生发展科研专项项目(首发2024-2-4372) Capital Health Development Research Special Project(shoufa 2024-2-4372)
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