转化生长因子β1基因突变对急性心肌梗死患者经皮冠状动脉介入治疗术后再狭窄的影响OA
Impact of transforming growth factor β1 gene mutation on restenosis in patients with acute myocardial infarction after percutaneous coronary intervention
目的 探讨转化生长因子β1(TGF-β1)基因突变对急性心肌梗死(AMI)患者经皮冠状动脉介入治疗(PCI)术后再狭窄的影响.方法 选取 2020 年 6 月至 2022 年 6 月于邢台市中心医院治疗的 120 例AMI患者为研究组,另选取同期 120 例于我院体检健康者为对照组,比较两组受试者TGF-β1基因突变情况.根据研究组患者PCI术后支架内再狭窄情况分为狭窄组(38例)和非狭窄组(82 例),比较两组患者临床资料,采用Logistic回归分析AMI患者PCI术后再狭窄的影响因素.结果 TGF-β1的509C/T位点存在3种基因型:CC、CT、TT,研究组CC基因型(33.33%比11.67%)以及C等位基因(55.83%比38.33%)频率高于对照组(χ2=17.131、14.750,P<0.05).120例AMI患者中38例PCI术后再狭窄,狭窄组CC基因型(52.63%比 24.39%)以及C等位基因(71.05%比 48.78%)频率高于非狭窄组,差异有统计学意义(χ2=10.221、10.447,P<0.05).狭窄组高血压、糖尿病比例以及低密度脂蛋白胆固醇、总胆固醇水平高于非狭窄组(χ2/t=7.408、6.213、3.159、2.416,P<0.05).高血压、糖尿病、TGF-β1 基因型(CC)均是AMI患者PCI术后再狭窄的影响因素(OR=1.589、1.725、1.624,P<0.05).结论 AMI患者TGF-β1 的509C/T位点CC基因型比例以及C等位基因频率更高,TGF-β1 的 509C/T位点基因型与PCI术后再狭窄存在相关性,其中CC基因型会增加AMI患者PCI术后再狭窄风险.
Objective To investigate the impact of transforming growth factor β1(TGF-β1)gene mutation on restenosis in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 120 AMI patients treated at Xingtai Central Hospital from June 2020 to June 2022 were selected as the study group,and 120 healthy individuals undergoing physical examinations at the hospital during the same period were selected as the control group.The mutation of TGF-β1 gene was compared between the two groups.According to the occurrence of in-stent restenosis after PCI,patients in the study group were further divided into a restenosis group(38 cases)and a non-restenosis group(82 cases).Medical records of the two groups were compared,and influencing factors for restenosis after PCI were analyzed using Logistic regression.Results Three genotypes were identified at the 509C/T locus of TGF-β1:CC,CT,and TT.The frequencies of the CC genotype(33.33%vs.11.67%)and the C allele(55.83%vs.38.33%)were higher in the study group than in the control group(χ2=17.131,14.750;P<0.05).Among the 120 AMI patients,38 cases had restenosis after PCI.The frequencies of the CC genotype(52.63%vs.24.39%)and the C allele(71.05%vs.48.78%)were higher in the restenosis group than in the non-restenosis group,with statistically significant differences(χ2=10.221,10.447;P<0.05).The proportions of hypertension and diabetes,as well as the levels of low-density lipoprotein cholesterol(LDL-C)and total cholesterol(TC),were higher in the restenosis group than in the non-restenosis group(χ2/t=7.408,6.213,3.159,2.416;P<0.05).Hypertension,diabetes,and the TGF-β1 CC genotype were the influencing factors for restenosis after PCI(OR=1.589,1.725,1.624;P<0.05).Conclusion AMI patients have a higher proportion of CC genotype and C allele frequency at the 509C/T locus of TGF-β1.The genotype at the 509C/T locus of TGF-β1 is correlated with restenosis after PCI,with the CC genotype increasing the risk of restenosis in AMI patients after PCI.
孙茹;郝晓辉;黄玲芳
054000 河北省邢台市中心医院心内科054000 河北省邢台市中心医院心内科054000 河北省邢台市中心医院心内科
转化生长因子β1基因突变急性心肌梗死经皮冠状动脉介入治疗再狭窄
Transforming growth factor β1Gene mutationAcute myocardial infarctionPercutaneous coronary interventionRestenosis
《心脑血管病防治》 2026 (2)
25-28,34,5
邢台市重点研发计划项目(2023ZC080)
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