Single-cell transcriptomic analysis of the terminal ileum identifies BCMA as a therapeutic target in IgA nephropathyOA
Single-cell transcriptomic analysis of the terminal ileum identifies BCMA as a therapeutic target in IgA nephropathy
Yuemiao Zhang;Jiawen Peng;Shaoqing Dang;Tong Xie;Hongyu Yang;Xin Zhang;Yang Li;Xujie Zhou;Lijun Liu;Sufang Shi;Timothy T.Lu;Lan Wang;Peter K.Wung;David James Haddon;Yanni Jiang;Naren Gaowa;Jicheng Lv;Zijie Zhang;Chunmei Li;Rui Cheng;Hong Zhang;Junze Wu;Na Wan;Xingzi Liu;Miaomiao Lin;Jingmei Li;Jingyu Wang;Jingyi Wu
Renal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaCandid Therapeutics Inc.,California,USARenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaCandid Therapeutics Inc.,California,USACandid Therapeutics Inc.,California,USACandid Therapeutics Inc.,California,USAEpimAb Biotherapeutics Inc.,Shanghai,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaState Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences,Yunnan University,Yunnan,China||Central Laboratory,Liver Disease Research Center and Department of Infectious Disease,The Affiliated Hospital of Yunnan University,Yunnan,ChinaState Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences,Yunnan University,Yunnan,ChinaState Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences,Yunnan University,Yunnan,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaState Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences,Yunnan University,Yunnan,ChinaState Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences,Yunnan University,Yunnan,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaDepartment of Integrated Traditional Chinese and Western Medicine,Peking University First Hospital,Institute of Integrated Traditional Chinese and Western Medicine,Peking University,Beijing,ChinaState Key Laboratory for Conservation and Utilization of Bio-resource and School of Life Sciences,Yunnan University,Yunnan,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,ChinaRenal Division,Peking University First Hospital,Peking University Institute of Nephrology,Key Laboratory of Renal Disease,Ministry of Health of China,Key Laboratory of Chronic Kidney Disease Prevention and Treatment(Peking University),Ministry of Education,Beijing,China
IgA nephropathymucosal immunityplasma cellIgA productionB-cell maturation antigen(BCMA)
IgA nephropathymucosal immunityplasma cellIgA productionB-cell maturation antigen(BCMA)
《微生物与宿主健康（英文）》 2026 (4)
233-248,16
The project was supported by grants from the National Natural Science Foundation of China(grant numbers 82170711 and 82470736 to Y.Z.82070733,92478202,and 22321005 to H.Z.32371000 to C.L.and 32500588 to R.C.),Beijing Nova Programme Interdisciplinary Cooperation Project(grant number 20240484677 to Y.Z.),Beijing Nova Programme(grant number 20220484147 to Y.Z.),Beijing Natural Science Foundation(grant number 7242144 to Y.Z.),the Fundamental Research Funds for the Central Universities(Peking University Clinical Sci-entist Training Program)(grant number BMU2024PYJH021to Y.Z.),the National High Level Hospital Clinical Research Fund-ing(Interdisciplinary Research Project of Peking University First Hospital)(grant number 2023IR12 to H.Z.),and CAMS Innovation Fund for Medical Sciences(grant number 2019-I2M-5-046 to H.Z.).
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