超声响应的MnCeFe层状三金属氢氧化物用于耐药菌感染治疗的研究OA

Multi-drug resistant(MDR)bacterial infections pose significant clinical challenges due to dense biofilm formation and the complex pathological microenvironment in infected areas.Ultrasound-responsive nanomaterials have shown promising potential in treating drug-resistant infections owing to their non-invasive nature,precise tar-geting of infected areas,and controllable generation of reactive oxygen species(ROS)to disrupt bacterial structures.In this study,we developed an ultrasound-responsive MnCeFe-layered trimetal hydroxide(MnCeFe LDH)nanoplat-form for effective treatment of drug-resistant bacterial infections.The MnCeFe LDH,synthesized via an optimized co-precipitation method,exhibited uniform size and stable dispersion.Under ultrasound irradiation,the material sig-nificantly enhanced ROS generation and glutathione depletion,with hydroxyl radicals(•OH),singlet oxygen(¹O₂),and superoxide anions(•O₂⁻)production increasing by 4.10-fold,1.75-fold,and 2.14-fold,respectively,com-pared to non-ultrasound conditions.Band structure analysis revealed that the abundant ROS generation originated from efficient redox catalytic processes among the variable valence states of Ce-Mn-Fe trimetal and that ultrasound-induced polarization effects promoted electron-hole separation and electron transfer.Vitro experiments demonstrated that the material achieved inhibition efficiencies of 93.7%and 97.3%against methicillin-resistant Staphylococcus au-reus(MRSA)and Escherichia coli ER2738 under ultrasound activation,along with biofilm degradation rates of 74.0%and 82.9%,respectively,indicating near-complete eradication of drug-resistant bacteria.This study pro-vides a novel and efficient nano-catalytic strategy for combating MDR bacterial infections.