基于数据挖掘探索《本草纲目》麻黄组方运用规律OA

Objective To analyze the prescriptions containing Herba Ephedrae in the Compendium of Materia Medica(本草纲目),explore their compatibility patterns,and provide an evidence base for the clinical application of Herba Ephedrae.Methods The Compen-dium of Materia Medica was used as the data source,and a database was established using Excel.Frequency analysis,association rule mining,clustering,and community structure analysis were conducted with SPSS Modeler,SPSS Statistics,and R studio to identify the compatibility patterns.Potential targets and pathways of core medicinal couplets were predicted using databases including TCMSP and STRING,along with Cytoscape software.Results A total of 58 prescriptions containing Herba Ephedrae were analyzed,involving 80 other medicinals.The medicinals were predominantly pungent,warm,and sweet in property,and most entered the lung meridian.High-frequency medicinals(used≥4 times)included Radix et Rhizoma Glycyrrhizae,Scorpio,Semen Armeniacae Amarum,and five others.The compatibilities primarily consisted of herbs for tonifying deficiency,releasing the exterior,and arresting cough and resolving phlegm.Core medicinal couplets included Herba Ephedrae-Rhizoma Atractylodis Macrocephalae,Herba Ephedrae-Scorpio,and Herba Ephedrae-Semen Armeniacae Amarum.The key predicted targets were AKT1,TNF,SRC,and TP53.These prescriptions were mainly indicated for diseases of the pulmonary system and epidemic diseases,covering 19 categories of disorders.Decoctions were the most common dosage form,followed by pills,powders,and wine-prepared forms.Conclusion Herba Ephedrae is primarily com-bined with tonifying medicinals and exterior-releasing medicinals.Data mining indicated that Herba Ephedrae-Scorpio is the core medicinal couplet for dispelling wind.Network pharmacology predictions suggest that this couplet may act on key targets such as AKT1 and TNF,regulating pathways like the neuroactive ligand-receptor interaction pathway,thereby implying potential neuroprotective and anti-inflammatory effects.Combining Herba Ephedrae with wine may enhance its sweat-inducing and blood-activating property,indicat-ing potential therapeutic benefits for conditions such as slow eruption of skin ulcers,postpartum blood stasis,and wind-cold impediment pain.