五加减正气散联合耳穴压豆治疗脾虚湿阻型腹泻型肠易激综合征OA
Clinical Observation on Wu Jiajian Zhengqi Powder(五加减正气散)combined with auricular point pressing with bean in the treatment of diarrhea-predominant irritable bowel syndrome with spleen deficiency and dampness obstruction
目的 观察五加减正气散联合耳穴压豆治疗脾虚湿阻型肠易激综合征(IBS-D)的临床疗效.方法 将70例脾虚湿阻型IBS-D患者随机分为试验组(35例,脱落2例,剔除1例)和对照组(35例,脱落1例).对照组给予枯草杆菌二联活菌肠溶胶囊口服,每次2粒(0.5g),每日3次,饭后30min温服;试验组给予中药五加减正气散联合中医外治法耳穴压豆,每次200ml,2次/d;耳豆每揉按3～5min,3次/d.14d为一疗程,共治疗2个疗程.分别于治疗前及治疗4周后记录两组患者中医证候积分、IBS病情严重程度量表(IBS-SSS)评分、IBS大便性状调查表(IBS-DSQ)评分、IBS生活质量测量量表(IBS-QOL)评分,观察两组临床疗效.结果 治疗后两组患者中医证候积分、IBS-SSS评分、IBS-DSQ评分、IBS-QOL评分均较治疗前降低(P<0.05),且试验组明显优于对照组(P<0.05);试验组腹泻、腹胀、肠鸣、畏寒、纳呆中医症状评分明显低于对照组(P＜0.01或P＜0.05).试验组总有效率为93.75%(30/32),高于对照组82.35%(28/34),差异具有统计学意义(P＜0.05).结论 五加减正气散联合耳穴压豆能有效改善脾虚湿阻型IBS-D患者腹泻、腹痛、腹胀、大便性状,可显著提高患者生活质量,患者依从性较高,反馈良好,值得进一步临床推广应用.
Objective To observe the clinical efficacy of Wu Jiajian Zhengqi Powder(五加减正气散,WJZP)combined with auricular point pressing with bean in the treatment of diarrhea type irritable bowel syndrome(IBS-D)with spleen deficiency and dampness obstruction.Methods A total of 70 patients with spleen deficiency and dampness obstruction type IBS-D were randomly divided into a treatment group(35 cases,2 dropouts,1 exclusion)and a control group(35 cases,1 dropout).The control group was administered oral Bacillus subtilis and Enterococcus faecium Enteric-coated Capsules,2 capsules(0.5 g)each time,three times daily,taken warm half an hour after meals.The treatment group was given WJZP combined with auricular point pressing with bean,200 ml each time,twice daily;the auricular seeds were massaged for 3-5 minutes each time,three times daily.One course of treatment lasted 14 days,and a total of two courses were administered.TCM syndrome scores,IBS Severity Scoring System(IBS-SSS)scores,IBS Bowel Symp-tom Questionnaire(IBS-DSQ)scores,and IBS Quality of Life(IBS-QOL)scores of both groups were recorded before treatment and 4 weeks after treatment to observe the clinical efficacy.Results After treatment,TCM syndrome scores,IBS-SSS scores,IBS-DSQ scores,and IBS-QOL scores of both groups were significantly lower than those before treatment(P<0.05),with the treatment group showing significantly better results than the control group(P<0.05).The TCM symptom scores for diarrhea,abdominal pain,and bloat-ing in treatment group were significantly lower than those in control group(P<0.01 or P<0.05),while there was no significant differ-ence in the scores for fatigue,cold intolerance,and poor appetite between the two groups(P>0.05).Overall effective rate in treatment group was 93.75%(30/32),which was higher than that in control group(82.35%,28/34)with a statistically significant difference(P<0.05).Conclusion WJZP combined with auricular point pressing with bean can effectively alleviate symptoms of diarrhea,abdominal pain,bloating,and stool consistency in patients with spleen deficiency and dampness obstruction type IBS-D.It can also significantly enhance the quality of life of patients,with high compliance and positive feedback,making it worthy of further clinical application and promotion.
潘海迪;梅笑;王子明;王伟;邓华亮
山东中医药大学第一临床医学院,山东 济南 250014山东中医药大学第一临床医学院,山东 济南 250014中国中医科学院广安门医院济南医院,山东 济南 250012山东中医药大学附属医院,山东 济南 250014山东中医药大学附属医院,山东 济南 250014
医药卫生
五加减正气散耳穴压豆腹泻型肠易激综合征随机对照试验
Wu Jiajian Zhengqi Powder(五加减正气散)Auricular point pressing with beanDiarrhea-predominant irritable bowel syndromeRandomized controlled trials
《时珍国医国药》 2026 (6)
1086-1091,6
国家中医药管理局科技司共建科技项目(GZY-KJS-SD-2023-035)国家自然科学基金青年基金(NO.81904128)山东省中医药疗效机理重点实验室(PKL2024C23)山东省中医药重点学科中医脾胃病学(鲁卫中医药科教字[2022]4号)山东省中医药科技项目(面上项目M-2023167)
评论