中西医融合视域下脑肠同调的创新与实践OA
Innovation and Practice of Brain-gut harmonization from the perspective of integrated tradi-tional Chinese and Western Medicine
脑肠同调作为一种中西医融合创新的疾病诊疗体系,通过整合中医学"脏腑相关""形神一体"整体观及现代医学"微生物-肠-脑轴"理论,系统阐释脑与肠之间跨器官、跨脏腑的双向生理病理联系.该理论针对功能性胃肠病、神经精神疾病、内分泌代谢疾病等脑肠共病,强调通过多靶点、整体性干预策略实现脑肠功能的协同调控,在临床实践中展现出其多维度干预的显著疗效.然而当前研究在理论融合、方法学整合与临床转化方面仍存在诸多挑战.未来亟需构建"病-证-症-期-生物标志物"新型医学融合体系,利用人工智能技术整合多维度数据,并推动高质量临床研究,从而促进脑肠同调理论从科学验证迈向广泛临床应用,为难治性疾病提供诊疗新范式.
Brain-gut harmonization is an innovative diagnostic and therapeutic system rooted in the integration of Chinese and Western medicine.It systematically elucidates the bidirectional physiological and pathological connections between the brain and the gut by syn-thesizing the holistic concepts of visceral correlation and body-mind unity from TCM with the modern microbiota-gut-brain(MGB)axis theory.Targeting brain-gut co-morbidities,such as functional gastrointestinal disorders,neuropsychiatric diseases,and endocrine-metabolic disorders,this approach emphasizes multi-target,holistic intervention strategies to achieve coordinated regulation of brain-gut function,demonstrating significant clinical efficacy through multidimensional interventions.However,current research still faces challenges in theoretical integration,methodological convergence,and clinical translation.Future efforts should focus on constructing a novel integrated medical framework based on"disease-pattern-symptom-stage-biomarker",utilizing artificial intelligence to synthesize multi-dimensional data,and promoting high-quality clinical research.This will advance brain-gut harmonization theory from scientific validation to widespread clinical application,offering a new paradigm for managing refractory diseases.
钱紫星;魏玮
湖北中医药大学中医学院,湖北 武汉 430065||中国中医科学院望京医院,北京 100102中国中医科学院望京医院,北京 100102
医药卫生
脑肠同调脑肠共病中西医融合微生物-肠-脑轴跨器官
Brain-gut harmonizationBrain-gut co-morbidityIntegration of Chinese and Western medicineMicrobiota-gut-brain axisCross-organ interaction
《时珍国医国药》 2026 (5)
801-806,6
国家重点研发计划中医药现代化专项(2023YFC3503601)国家自然科学基金区域创新发展联合基金(U22A20375)国家中医药传承创新团队项目(ZYYCXTD-C-202210)中国中医科学院望京医院自主选题专项课题(WJYY-ZZXT-2025-34)
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