非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值与中老年人发生全因死亡的关系:基于CHARLS的横断面研究OA
Relationship between NHHR and All-Cause Death in Middle-Aged and Elderly People:a Cross-Sectional Study Based on CHARLS
目的 基于中国健康与养老追踪调查(CHARLS)探讨非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值(NHHR)与中老年人发生全因死亡的关系.方法 选取CHARLS 2011、2013、2015、2018年数据中10 318例中老年人的数据.在2011年CHARLS数据中收集中老年人的临床资料,在2013、2015、2018年CHARLS数据中收集中老年人全因死亡发生情况.根据中老年人全因死亡发生情况将其分为死亡组与无死亡组.绘制限制性立方样条(RCS)图以分析NHHR与中老年人全因死亡发生风险的剂量-反应关系,采用多元Cox比例风险回归分析探讨NHHR与中老年人发生全因死亡的关系.结果 10 318例中老年人中,发生全因死亡1 077例(10.44%).死亡组与无死亡组年龄、性别、文化程度、婚姻状况、吸烟发生率、饮酒情况、高血压发生率、糖尿病发生率、尿酸(UA)、TG、TC、空腹血糖(FPG)、糖化血红蛋白(HbA1c)比较,差异有统计学意义(P＜0.05).RCS图分析结果显示,NHHR与中老年人全因死亡发生风险呈双拐点U型关联(P整体=0.003,P非线性＜0.001),最低风险点为3.71,风险拐点分别为2.82、4.83.将NHHR分为＜2.82(n=5 137)、2.82～3.71(n=2 440)、2.72～4.83(n=1 632)、＞4.83(n=1 109)4个亚组.多元Cox比例风险回归分析结果显示,NHHR＜2.82[HR=0.80,95%CI(0.68～0.96)]是中老年人发生全因死亡的保护因素,NHHR＞4.83[HR=1.06,95%CI(1.02～1.11)]是其危险因素(P＜0.05).结论 NHHR＜2.82是中老年人发生全因死亡的保护因素,NHHR＞4.83是其危险因素.
Objective To discuss the relationship between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio(NHHR)and all-cause death in middle-aged and elderly people based on the China Health and Retirement Longitudinal Study(CHARLS).Methods The data of 10 318 middle-aged and elderly people from the 2011,2013,2015,and 2018 datasets of CHARLS.Clinical data of the middle-aged and elderly people in the 2011 CHARLS data were collected,the occurrence of all-cause mortality of the middle-aged and elderly people in the 2013,2015,2018 CHARLS data was collected,and middle-aged and elderly people were divided into the death group and the non-death group according to the occurrence of all-cause death.Restricted cubic spline(RCS)plot was drawn to analyze the dose-response relationship between NHHR and all-cause death risk in middle-aged and elderly people.Multivariate Cox proportional hazards regression analysis was used to discuss the relationship between NHHR and all-cause death in middle-aged and elderly people.Results Among the 10 318 cases of middle-aged and elderly people,1 077 cases occurred all-cause death(accounting for 10.44%).There were significant differences in age,gender,education level,marital status,incidence of smoking,drinking situation,incidence of hypertension,incidence of diabetes,uric acid(UA),TG,TC,fasting plasma glucose(FPG),and glycated hemoglobin(HbA1c)between the death group and the non-death group(P<0.05).The RCS plot analysis results indicated that the association between NHHR and all-cause death risk in middle-aged and elderly people showed a U-shaped double inflection point(Pfor overall=0.003,Pfor nonlinear<0.001).The point of lowest risk was 3.71,and the risk inflection points were 2.82 and 4.83 respectively.The NHHR was divided into the four subgroups:<2.82(n=5 137),2.82-3.71(n=2 440),3.72-4.83(n=1 632),and>4.83(n=1 109).Multivariate Cox proportional hazards regression analysis results showed that NHHR<2.82[HR=0.80,95%CI(0.68-0.96)]was a protective factor of all-cause death in middle-aged and elderly people,NHHR>4.83[HR=1.06,95%CI(1.02-1.11)]was its risk factor(P<0.05).Conclusion NHHR<2.82 is a protective factor of all-cause death in middle-aged and elderly people,and NHHR>4.83 is its risk factor.
刘硕;郝杰;方奎;王锐
110001 辽宁省沈阳市,中国医科大学附属第一医院介入手术室430071 湖北省武汉市,武汉大学护理学院430071 湖北省武汉市,武汉大学护理学院||110001 辽宁省沈阳市,中国医科大学附属第一医院神经外科110001 辽宁省沈阳市,中国医科大学附属第一医院神经外科
医药卫生
胆固醇,HDL全因死亡中老年人非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇比值中国健康与养老追踪调查
Cholesterol,HDLAll-cause deathMiddle-aged and elderly peopleNHHRChina Health and Retirement Longitudinal Study
《实用心脑肺血管病杂志》 2026 (5)
47-51,5
国家自然科学基金青年科学基金项目(82103450)
评论