血尿酸/高密度脂蛋白胆固醇比值与青年和中老年人群发生代谢综合征的关系:一项横断面研究OA

Objective To investigate the association between serum uric acid to high-density lipoprotein cholesterol ratio(UHR)and metabolic syndrome(MS)in young and middle-aged populations.Methods A total of 1 066 individuals who underwent health examinations at the Dongguan Community Health Service Center in Yongqiao District,Suzhou City from December 2021 to January 2022 were selected as the research subjects.The clinical data of the subjects were collected,and they were divided into a youth group(<45 years old)and a middle-aged and elderly group(≥45 years old)based on age.The subjects of the youth group were divided into the MS1 subgroup and the non-MS1 subgroup according to whether MS was diagnosed,and the subjects of the middle-aged and elderly group were divided into the MS2 subgroup and the non-MS2 subgroup.Multivariate Logistic regression analysis was used to explore the influencing factors of MS in the youth group and the middle-aged and elderly group.The ROC curve was used to explore the predictive value of the UHR for MS in the youth group and the middle-aged and elderly group.Results Among the 1 066 subjects,631 in the young group and 435 in the middle-aged and elderly group.The MS detection rate in the middle-aged and elderly group was higher than that in the youth group,serum uric acid and UHR were lower than those in the youth group(P<0.05).Four hundred and ninety-three subjects were in the non-MS1 subgroup,138 subjects were in the MS1 subgroup.The proportion of males,the proportion of people with smoking history,the proportion of people with drinking history,body mass index(BMI),systolic blood pressure,diastolic blood pressure,triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),fasting blood glucose(FBG),blood creatinine,blood uric acid,UHR in the MS1 subgroup were higher than those in the non-MS1 subgroup,age,waist circumference were greater than those in the non-MS1 subgroup,the proportion of people with junior college and above,high density lipoprotein cholesterol(HDL-C)were lower than those in the MS1 subgroup,brachial-ankle pulse wave velocity(baPWV)was faster than that in the non-MS1 subgroup(P<0.05).Two hundred and ninety-one subjects were in the non-MS2 subgroup,144 subjects were in the MS2 subgroup.The proportion of people with smoking history,BMI,systolic blood pressure,diastolic blood pressure,TG,FBG,blood creatinine,blood uric acid,UHR in the MS2 subgroup were higher than those in the non-MS2 subgroup,waist circumference was greater than that in the non-MS2 subgroup,while the HDL-C was lower than that in the non-MS2 group(P<0.05).Multivariate Logistic regression analysis showed that age,smoking history,BMI,TG,TC,LDL-C,FBG,UHR were independent influencing factors of MS in the youth group(P<0.05),BMI,waist circumference,TG,FBG,UHR were independent influencing factors of MS in the middle-aged and elderly group(P<0.05).ROC curve analysis showed that the AUC of UHR in predicting MS in the youth group was 0.872[95%CI(0.839-0.905)],the AUC of UHR in predicting MS in the middle-aged and elderly group was 0.800[95%CI(0.754-0.846)].The AUC of UHR in predicting MS in the youth group was higher than the AUC of UHR in predicting MS in the middle-aged and elderly group(P<0.05).Conclusion The MS detection rate in the middle-aged and elderly population is higher than that in the young population,and UHR is lower than that in the young population.UHR is an independent influencing factor of MS in the young population and the middle-aged and elderly population,and it holds greater predictive value for MS in the young population.