青海地区阻塞性睡眠呼吸暂停相关性高血压患者颈动脉粥样硬化的危险因素分析OA
Risk Factors of Carotid Atherosclerosis in Patients with Obstructive Sleep Apnea-Related Hypertension in Qinghai
目的 探讨青海地区阻塞性睡眠呼吸暂停(OSA)相关性高血压患者颈动脉粥样硬化的危险因素.方法 选取2023年3月—2024年3月就诊于青海省心脑血管病专科医院的OSA相关性高血压患者169例为研究对象.收集患者的一般资料、入院时实验室检查指标、睡眠监测指标、动态血压监测指标.根据颈动脉粥样硬化情况将患者分为对照组(颈动脉正常,n=57)、早期亚临床动脉粥样硬化(eSA)组(eSA,n=60)、斑块组(颈动脉粥样硬化斑块形成,n=52).OSA相关性高血压患者颈动脉粥样硬化危险因素分析采用多元Logistic回归分析.结果 eSA组年龄大于对照组,斑块组年龄大于对照组和eSA组(P＜0.05);斑块组载脂蛋白B(ApoB)、丙二醛(MDA)、呼吸暂停低通气指数(AHI)、氧减指数(ODI)、24 h平均收缩压、夜间平均收缩压、夜间收缩压负荷高于对照组,收缩压夜间下降率、舒张压夜间下降率低于对照组,最低血氧饱和度低于对照组和eSA组(P＜0.05).多元Logistic回归分析结果显示,年龄增长[OR=1.064,95%CI(1.016～1.113)]是OSA相关性高血压患者发生eSA的危险因素(P＜0.05),年龄增长[OR=1.134,95%CI(1.072～1.200)]、ApoB升高[OR=10.766,95%CI(1.172～98.874)]、MDA升高[OR=1.920,95%CI(1.233～3.014)]是OSA相关性高血压患者发生颈动脉粥样硬化斑块形成的危险因素(P＜0.05).结论 年龄增长是OSA相关性高血压患者发生eSA的危险因素;年龄增长、ApoB升高、MDA升高是OSA相关性高血压患者发生颈动脉粥样硬化斑块形成的危险因素.
Objective To investigate the risk factors of carotid atherosclerosis in patients with obstructive sleep apnea(OSA)-related hypertension in Qinghai.Methods A total of 169 patients with OSA-related hypertension admitted to Qinghai Special Hospital for Cardio-Cerebrovascular Diseases from March 2023 to March 2024 were selected as the research subjects.The general information,laboratory inspection indicators,sleep monitoring indicators,and dynamic blood pressure monitoring indicators on admission of patients were collected,and patients were divided into control group(normal carotid artery,n=57),early subclinical atherosclerosis(eSA)group(eSA,n=60)and plaque group(carotid atherosclerotic plaque formation,n=52)according to carotid atherosclerosis.Multiple Logistic regression analysis was used to explore the risk factors of carotid atherosclerosis in patients with OSA-related hypertension.Results The age in the eSA group was older than that in the control group,the age in the plaque group was older than that in the control group and the eSA group(P<0.05).The apolipoprotein B(ApoB),malondialdehyde(MDA),apnea-hypopnea index(AHI),oxygen desaturation index(ODI),24-hour average systolic blood pressure,nighttime average systolic blood pressure,and nighttime systolic blood pressure in the plaque group were higher than those in the control group,the nighttime decrease rates of systolic blood pressure and diastolic blood pressure were lower than those in the control group,and the lowest blood oxygen saturation was lower than that in the control group and eSA group(P<0.05).Multiple Logistic regression analysis showed that increased age[OR=1.064,95%CI(1.016-11.113)]was a risk factor for eSA in patients with OSA-related hypertension(P<0.05);increased age[OR=1.134,95%CI(1.072-1.200)],increased ApoB[OR=10.766,95%CI(1.172-98.874)],increased MDA[OR=1.920,95%CI(1.233-3.014)]were risk factors for carotid atherosclerosis plaque formation in patients with OSA-related hypertension(P<0.05).Conclusion Increased age is a risk factor for eSA in patients with OSA-related hypertension;increased age,increased ApoB and increased MDA are risk factors for carotid atherosclerosis plaque formation in patients with OSA-related hypertension.
王银梅;汪晓洲
810000 青海省西宁市,青海省心脑血管病专科医院高血压科810000 青海省西宁市,青海省心脑血管病专科医院高血压科
医药卫生
高血压睡眠呼吸暂停,阻塞性动脉粥样硬化危险因素
HypertensionSleep apnea,obstructiveAtherosclerosisRisk factors
《实用心脑肺血管病杂志》 2026 (5)
31-35,5
2022年度青海省"昆仑英才·高端创新创业人才"项目培养领军人才
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