踝肱指数与老年高血压患者发生心脑血管死亡的关系研究OA

Objective To investigate the relationship between ankle-brachial index(ABI)and incidence of cardio-cerebrovascular death in elderly hypertensive patients.Methods A total of 1 202 patients with hypertension who received treatment at Mianyang Central Hospital from March to June 2021 were selected as the study participants.Clinical data of the patients were collected.After 3 years of follow-up,patients were divided into the cardio-cerebrovascular death group and the non-cardio-cerebrovascular death group according to the occurrence of cardio-cerebrovascular death.Generalized additive model was used to analyze the correlation between ABI and the risk of cardio-cerebrovascular death in elderly hypertensive patients,and multivariate Cox proportional hazards regression analysis was used to analyze the relationship between ABI and the risk of cardio-cerebrovascular death in elderly hypertensive patients.Results After 3 years of follow-up,516 patients with missing ABI data and 6 patients lost to follow-up were excluded,ultimately 680 patients were enrolled.Among the 680 patients,43 cases(6.32%)happened cardio-cerebrovascular death.The smoking rate,drinking rate,proportion of patients with chronic kidney disease in the cardio-cerebrovascular death group were higher than those in the non-cardio-cerebrovascular death group,triglyceride,low-density lipoprotein cholesterol,and ABI were lower than those in the non-cardio-cerebrovascular death group(P<0.05).Generalized additive model analysis results revealed that ABI exhibited a"L"-shaped nonlinear correlation with cardio-cerebrovascular death in elderly hypertensive patients(P for overall=0.023,P for nonlinear=0.005),and with the lowest inflection point at 1.16.Multivariate Cox proportional hazards regression analysis results showed that ABI<1.16 was an independent risk factor for cardio-cerebrovascular death in elderly hypertensive patients(P<0.001).Conclusion ABI exhibits a"L"-shaped nonlinear correlation with cardio-cerebrovascular death in elderly hypertensive patients,and ABI<1.16 is an independent risk factor for cardio-cerebrovascular death in patients with hypertension.