同型半胱氨酸与心脑血管疾病的关系及其干预界值争议OA

In China,the number of patients with H-type hypertension(hypertension combined with hyperhomocysteinemia)accounts for 75%of the total number of patients with hypertension,and the disease is the primary controllable risk factor for stroke.However,the optimal intervention threshold of homocysteine(Hcy)has not yet reached a consensus.Based on this,this paper integrates the existing research evidence,and reviews the relationship between Hcy and cardiovascular and cerebrovascular diseases and deeply analyzes the controversy of Hcy intervention threshold.It finds that elevated Hcy levels serve as an independent risk factor for cardiovascular and cerebrovascular diseases,correlating with disease risk and adverse outcomes,with varying impacts on prognosis depending on the degree of Hcy elevation.Currently,major academic institutions worldwide hold differing views on Hcy intervention thresholds,with some supporting a higher threshold(15 μmol/L),others advocating for a lower threshold(10 μmol/L),and still others proposing alternative thresholds.