抗幽门螺杆菌治疗后出现吉兰-巴雷综合征:1例报告及文献复习OA

Objective:To enhance the clinical understanding of the correlation between Helicobacter pylori(Hp)and Guillain-Barre syndrome(GBS). Methods:This paper reports the clinical diagnosis and treatment process of a patient with GBS caused by Hp infection.Combined with literature review,the correlation between Hp and GBS is mainly explored. Results:The patient had an acute onset and a history of Hp infection.The initial manifestation was gastrointestinal symptoms,which gradually worsen,leading to symmetrical weakness in both lower limbs and weakened tendon reflexes.Cerebrospinal fluid examination revealed protein-cell dissociation.Electrophysiological examination indicated demyelinating changes in peripheral nerves,manifested as prolonged distal motor nerve conduction latency,slowed conduction velocity,abnormal F-waves,conduction block and waveform dispersion.The patient was ultimately diagnosed with GBS.After standard immunotherapy,the patient had a good prognosis. Conclusion:For the acute occurrence of digestive symptoms and peripheral nervous system-related symptoms in patients with Hp infection,it is particularly important in clinical practice to identify early whether GBS is induced by Hp infection,in order to achieve early diagnosis and early treatment and improve the prognosis of patients.