中药及复方调控小胶质细胞焦亡改善血管性痴呆的研究分析与探讨OA

Vascular dementia(VaD)refers to a clinical syndrome characterized by cognitive decline caused by cerebrovascular diseases.It not only directly impairs the structure and function of nerves,but also has become one of the most common chronic diseases threatening the quality of life of the elderly.In recent years,many studies have found that pyroptosis accompanied by inflammatory responses is one of the main forms of nerve damage in VaD.This programmed cell death method exacerbates the neuroinflammatory cascade reaction and accelerates the decline of cognitive impairment by releasing pro-inflammatory factors,providing a theoretical basis for exploring potential treatment methods and intervention mechanisms for VaD.Traditional Chinese medicine(TCM)has rich clinical experience and definite efficacy in the treatment of VaD.Its characteristics of multiple targets,multiple pathways,multiple components,and few adverse reactions can delay the progression of VaD and improve clinical symptoms.Based on this,by focusing on the pathological link of microglial pyroptosis,this paper aims to sort out the research progress of effective TCM components and classic compound prescriptions in intervening in VaD through systematic retrieval and in-depth analysis of relevant literatures in recent years.It focuses on summarizing the relevant potential signaling pathways that reduce nerve cell damage by regulating microglial pyroptosis and the activation state of microglia,reveals the potential value and prevention potential of TCM in the prevention and treatment of VaD from the perspective of microglial pyroptosis,and provides new ideas and more experimental evidence for the clinical application of TCM in the treatment of VaD.