成纤维细胞生长因子21与老年人内在能力的相关性研究OA

Objective To examine the association between plasma fibroblast growth factor(FGF)-21 levels and intrinsic capacity(IC)among community-dwelling older adults.Methods A cross-sectional survey was conducted from February to August 2023 in four communities in Beijing.We enrolled 671 residents aged≥60 years and collected information on demographics,physical examinations,and plasma samples.Intrinsic capacity was evaluated according to the 2015 WHO framework across five domainsand classified as normal IC(9-10 points)or declined IC(0-8 points).Plasma FGF-21 concentrations were quantified by enzyme-linked immunosorbent assay and categorized into low,medium,and high tertiles.Spearman correlation coefficients were calculated to assess the relationship between FGF-21 levels and IC scores.Multivariable logistic regression and Receiver operating characteristic(ROC)curve analyses were employed to determine the impact and discriminative ability of FGF-21 for identifying IC decline.Results Among the participants,249(37.11％)exhibited IC decline.FGF-21 levels were significantly higher in the normal-IC group than in the declined-IC group[3.23(2.78,3.88)ng/L vs 2.81(2.48,3.31)ng/L;Z=-6.255,P＜0.001].FGF-21 concentrations were positively correlated with locomotion,cognition,and sensory function.After adjustment for demographic characteristics,lifestyle behaviors,and comorbidities,the odds ratios for IC decline in the medium and high FGF-21 tertiles versus the low tertile were 0.58(95％CI:0.36-0.94,P=0.029)and 0.41(95％CI:0.24-0.68,P=0.001),respectively.The area under the ROC curve was 0.644(95％CI:0.602-0.691).Conclusions Higher plasma FGF-21 levels are positively associated with intrinsic capacity in older adults and may have identification value for IC decline,highlighting its potential as a biomarker and therapeutic target.