螺旋断层放疗系统自适应放疗治疗肺癌的临床效果OA
Clinical efficacy of adaptive radiotherapy with helical tomotherapy in the treatment of lung cancer
目的 探讨螺旋断层放疗系统(TOMO)自适应放疗治疗肺癌的临床效果.方法 选取2020年9月—2023年12月收治的行放疗的肺癌患者60例,按放疗方式分为对照组和观察组各30例,将接受常规直线加速器非自适应放疗的30例患者纳入对照组,接受TOMO自适应放疗的30例患者纳入观察组.比较两组近期疗效及放疗相关不良反应发生情况,绘制K-M生存曲线分析两组无进展生存和总生存情况,采用Cox单因素及多因素分析肺癌放疗患者生存的影响因素.结果 观察组客观缓解率、疾病控制率[83.33%(25/30)、96.67%(29/30)]较对照组[56.67%(17/30)、73.33%(22/30)]高(P<0.05);观察组放疗相关不良反应总发生率[10.00%(3/30)]较对照组[43.33%(13/30)]低(P<0.01).K-M生存曲线显示,观察组累积无进展生存率、累积总生存率(39.70%、45.40%)较对照组(16.20%、21.70%)高(P<0.05).Cox单因素与多因素分析均显示,TNM分期、放疗方式是肺癌放疗患者无进展生存和总生存的影响因素(P<0.05).结论 应用TOMO自适应放疗治疗肺癌可显著提升近期疗效,减少不良反应,改善预后;但TNM分期、放疗方式是无进展生存、总生存的影响因素,临床应予以重视.
Objective To investigate the clinical efficacy of adaptive radiotherapy with helical tomotherapy(TOMO)in the treatment of lung cancer.Methods Sixty patients with lung cancer who underwent radiotherapy between September 2020 and December 2023 were selected.They were divided into the control group(n=30)and the observation group(n=30)according to different radiotherapy methods.Thirty patients who underwent conventional non-adaptive radiotherapy with linear accelerator were included in the control group,and thirty patients who underwent adaptive radiotherapy with TOMO were included in the observation group.The short-term efficacy and the incidence of radiotherapy-related adverse reactions were compared between the two groups.K-M survival curve was drawn to analyze progression-free survival(PFS)and overall survival(OS)of the two groups.Univariate Cox regression analysis and multivariate analysis were used to identify factors affecting the survival of patients undergoing radiotherapy for lung cancer.Results The objective response rate and disease control rate of the observation group[83.33%(25/30)and 96.67%(29/30)]were higher than those of the control group[56.67%(17/30)and 73.33%(22/30)](P<0.05),while the total incidence of radiotherapy-related adverse reactions in the observation group[10.00%(3/30)]was lower than that in the control group[43.33%(13/30)](P<0.05).K-M survival curve showed that cumulative PFS and cumulative OS of the observation group(39.70% and 45.40%)were higher than those of the control group(16.20% and 21.70%)(P<0.05).Univariate and multivariate Cox regression analyses showed that TNM staging and radiotherapy method were factors affecting PFS and OS of patients undergoing radiotherapy for lung cancer(P<0.05).Conclusion Applying adaptive radiotherapy with TOMO to treat lung cancer can significantly improve short-term efficacy,reduce adverse reactions and enhance prognosis.However,TNM staging and radiotherapy method are factors affecting PFS and OS,which deserves close attention in clinical practice.
郭艺航;王立鹏;李唯源;张漫玉;冯庆;赵佳明
唐山中心医院放射治疗科,河北 唐山 063006唐山中心医院肿瘤科,河北 唐山 063006华北理工大学附属医院放化疗四科,河北 唐山 063000唐山中心医院肿瘤科,河北 唐山 063006唐山中心医院放射治疗科,河北 唐山 063006唐山中心医院放射治疗科,河北 唐山 063006
肺肿瘤螺旋断层放疗系统自适应放疗放疗相关不良反应预后影响因素TNM分期放疗方式
lung cancerhelical tomotherapyadaptive radiotherapyradiotherapy-related adverse reactionsprognosisinfluencing factorsTNM stagingradiotherapy method
《临床误诊误治》 2026 (6)
26-30,36,6
河北省医学科学研究课题计划资助(20221852)
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