血脑屏障穿透肽的研究进展OA

As more peptide drugs are increasingly entering the market,cell-penetrating peptides(CPPs)have attracted much attention due to their low toxicity,high target specificity and tolerability.CPPs targeting the central nervous system are able to transport therapeutic cargoes across the blood-brain barrier(BBB),offering novel strategies for treating the central nervous system(CNS)disorders,including Alzheimer's disease,Parkinson's disease,brain tumors,and neurotropic viral infections.This review summarizes the structural characteristics of blood-brain barrier-penetrating peptides,elucidates their mechanisms of cellular internalization,and outlines their applications in the treatment of CNS diseases.