新型等离子针状电极膀胱肿瘤整块切除术治疗老年NMIBC的疗效及术后复发的影响因素OA
Efficacy of novel plasma needle electrode for en bloc resection of bladder tumor in treating elderly NMIBC and factors influencing postoperative recurrence
目的 探究新型等离子针状电极膀胱肿瘤整块切除术治疗老年非肌层浸润性膀胱癌(NMIBC)的疗效及术后复发的影响因素.方法 回顾性分析2021年3月—2023年11月于首都医科大学附属北京友谊医院接受新型等离子针状电极治疗的134例老年NMIBC患者的临床资料.采用单因素分析探讨性别、年龄、身体质量指数(BMI)、合并症情况、吸烟史、饮酒史、病理诊断、T分期、肿瘤分级、肿瘤位置、肿瘤数量与复发的关系,并进一步采用Cox回归分析确定术后复发的独立影响因素,分析各变量对患者无复发累积生存率的影响.结果 所有患者均顺利完成手术,肿瘤切除效果满意,未发生严重并发症.术后1年内无复发98例,复发36例,复发率为26.87%.单因素分析结果显示,复发与无复发患者在年龄、合并高血压、合并糖尿病、T分期、肿瘤分级、肿瘤数量方面的差异有统计学意义(P<0.05);多因素分析结果显示,年龄、合并高血压、合并糖尿病、T分期、肿瘤分级、肿瘤数量均是患者术后复发的独立影响因素(P<0.05);不同年龄、合并高血压情况、合并糖尿病情况、T分期、肿瘤分级、肿瘤数量患者无复发累积生存率比较,差异均有统计学意义(P<0.05).结论 新型等离子针状电极治疗老年NMIBC的疗效良好,但术后1年内肿瘤复发率较高.年龄、合并高血压、合并糖尿病、T分期、肿瘤分级、肿瘤数量均为术后复发的独立影响因素.临床应加强术前评估、优化合并症管理及术后密切随访以早期干预复发.
Objective To investigate the efficacy of en bloc resection of bladder tumor(ERBT)using a novel plasma needle electrode in elderly patients with non-muscle invasive bladder cancer(NMIBC)and the factors influencing postoperative recurrence.Methods Clinical data of 134 elderly NMIBC patients who underwent ERBT with a novel plasma needle electrode at Beijing Friendship Hospi-tal,Capital Medical University from March 2021 to November 2023 were retrospectively analyzed.Univariate analysis was used to explore the association of gender,age,body mass index(BMI),comorbidities,smoking history,alcohol history,pathological diag-nosis,T stage,tumor grade,tumor location,and tumor number with recurrence.Cox regression analysis was further employed to identify independent factors influencing postoperative recurrence and to analyze the impact of each variable on recurrence-free cumula-tive survival rate.Results All patients successfully underwent surgery with satisfactory tumor resection and no serious complica-tions.Within one year postoperatively,98 patients remained recurrence-free,while 36 experienced recurrence,yielding a recurrence rate of 26.87%.Univariate analysis showed statistically significant differences between recurrence and non-recurrence groups in age,combined hypertension,combined diabetes mellitus,T stage,tumor grade,and tumor number(P<0.05).Multivariate analysis i-dentified age,combined hypertension,combined diabetes mellitus,T stage,tumor grade,and tumor number as independent factors influencing postoperative recurrence(P<0.05).Significant differences were observed in recurrence-free cumulative survival rates a-mong patients with different ages,combined hypertension status,combined diabetes status,T stages,tumor grades,and tumor numbers(P<0.05).Conclusion ERBT with a novel plasma needle electrode demonstrates favorable efficacy in elderly NMIBC pa-tients;however,the tumor recurrence rate within one year postoperatively remains relatively high.Age,combined hypertension,combined diabetes mellitus,T stage,tumor grade,and tumor number are independent factors influencing postoperative recurrence.Enhanced preoperative assessment,optimized comorbidity management,and close postoperative follow-up should be emphasized for early intervention of recurrence.
张艳红;陈娜;王薇;王倩;孙齐蔓;刘浩楠;秦美珊
首都医科大学附属北京友谊医院泌尿外科,北京 100050首都医科大学附属北京友谊医院泌尿外科,北京 100050首都医科大学附属北京友谊医院泌尿外科,北京 100050首都医科大学附属北京友谊医院泌尿外科,北京 100050首都医科大学附属北京友谊医院泌尿外科,北京 100050首都医科大学附属北京友谊医院泌尿外科,北京 100050首都医科大学附属北京友谊医院泌尿外科,北京 100050
医药卫生
新型等离子针状电极膀胱肿瘤整块切除术非肌层浸润性膀胱癌疗效
Novel plasma needle electrodeEn bloc resection of bladder tumorNon-muscle invasive bladder cancerEfficacy
《保健医学研究与实践》 2026 (1)
58-65,8
首都卫生发展科研专项项目(首发2022-2G-2208).
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