胶质-血管单元参与皮层扩散性抑制进程的研究进展OA
Research Progress on the Involvement of the Glial-Vascular Unit in Cortical Spreading Depression
皮层扩散性抑制(cortical spreading depression,CSD)是偏头痛、脑缺血等多种神经系统疾病的关键病理事件.最新研究表明,胶质-血管单元(glial-vascularunit,GVU)是调控CSD进程的核心拮构.本综述系统阐述了 GVU各组分在CSD中的动态作用与机制:星形胶质细胞作为核心枢纽,在CSD中发挥损伤与保护并存的双重调控作用;小胶质细胞作为CSD的起始细胞之一,参与损伤与修复的双向过程;周细胞在CSD后出现异常收缩,介导持续性毛细血管低灌注;血管周围间隙及胶质-淋巴系统的功能改变,是影响CSD发生与恢复的潜在因素.GVU内部各组分的协同与拮抗关系决定了疾病进程,这一认识将研究焦点从过去的单一细胞或组分拓展至GVU这一整体,为深入理解CSD病理生理全过程及开发多靶点协同治疗策略提供了全新视角.
Cortical spreading depression(CSD)is a key pathological event in various neurological disorders such as migraine and cerebral ischemia.Recent research reveals that the glial-vascular unit(GVU)serves as a central platform regulating the CSD process.This review systematically elucidates the dynamic roles and mechanisms of GVU components in CSD:the dual functions of astrocytes as central hubs;microglia acting as one of initiating cells potentially involved in both damaging and reparative effects;abnormal post-CSD contraction of pericytes mediating sustained capillary hypoperfusion;while functional alterations in the perivascular space and glymphatic system may represent potential factors influencing CSD initiation and recovery.These findings establish the GVU as the core regulatory platform for CSD,whose internal synergy and conflicts determine disease progression.This shifts the research focus from individual components to the entire GVU,providing novel perspectives for comprehensively understanding CSD pathophysiology and developing multi-target synergistic therapeutic strategies.
杨霄;姚笛;汪明欢
华中科技大学同济医学院附属同济医院神经内科 武汉 430030华中科技大学同济医学院附属同济医院神经内科 武汉 430030华中科技大学同济医学院附属同济医院神经内科 武汉 430030
医药卫生
胶质细胞皮层扩散性抑制胶质-血管单元
glial cellscortical spreading depressionglial-vascular unit
《神经损伤与功能重建》 2026 (3)
156-161,6
湖北省自然科学基金(脑小血管病介导认知功能损害的机制及干预靶点,No.2022CFA097)国家自然科学基金(mLVs-Glymphatic系统在急性脑梗塞后神经血管单元损伤与功能重塑中的作用及机制研究,No.822713559)国家自然青年科学基金项目(Col3a1+周细胞介导AQP4极化调控Glymphatic系统功能——血管性认知障碍的干预新靶点?,No.82401566)
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