线粒体自噬在糖尿病周围神经病变中的作用OA

Diabetic peripheral neuropathy(DPN)is one of the most common chronic complications of diabetes and seriously affects patients'quality of life.Its pathogenesis is complex and involves multiple pathological processes,including metabolic disorders,oxidative stress,and mitochondrial dysfunction.In recent years,mitophagy,as a key cellular quality-control mechanism for the selective removal of damaged mitochondria,has received increasing attention in DPN.Studies have shown that mitophagy can regulate the progression of DPN by maintaining mitochondrial homeostasis and alleviating oxidative stress and inflammatory responses.At present,the specific molecular mechanisms and potential therapeutic value of mitophagy in DPN remain unclear and require further in-depth investigation.A systematic summary of the molecular regulatory network of mitophagy,an in-depth discussion of its role in the occurrence and development of DPN,and an analysis of therapeutic strategies targeting mitophagy and their clinical application prospects are expected to provide a theoretical basis and research ideas for understanding the pathogenesis of DPN and developing innovative treatment strategies.