DNA甲基化与口腔扁平苔藓的发病机制OA

Oral lichen planus(OLP)is a chronic inflammatory disease of the oral mucosa with a high incidence,characterized primarily by T-cell-mediated immune dysregulation and carrying a potential risk of malignant transformation.DNA methylation,as an important epigenetic regulatory mechanism,participates in the pathogenesis of OLP by influencing the expression of immune-related genes.Environmental factors and genetic polymorphisms can lead to abnormal DNA methylation patterns,thereby affecting T cell function,cytokine secretion,and the regulation of inflammatory responses.In patients with OLP,characteristic methylation alterations have been identified in various immune-related genes,microRNAs,and transcription factors.These changes not only participate in the occurrence and development of the disease but are also closely associated with disease activity and malignant transformation.DNA methylation,through the regulation of gene expression,has been increasingly studied in relation to pathogenesis,disease assessment,and prediction of malignant transformation in OLP,providing important theoretical support for the development of novel diagnostic biomarkers and targeted therapeutic strategies.