哺乳动物雷帕霉素靶蛋白信号通路调控神经炎症在癫痫发病机制中的研究进展OA

Epilepsy is caused by abnormal hypersynchronous discharge of neurons in the brain and is characterized by recurrent seizures.The exact pathogenesis of epilepsy remains unknown due to its complex etiology.The mammalian target of rapamycin(mTOR)can regulate fundamental cellular functions such as growth,metabolism,and proliferation and affect immune function by integrating signals from the immune microenvironment.Abnormalities in the mTOR signaling pathway are one of the key mechanisms for epilepsy associated with genetically mediated structural lesions.Extensive studies have been conducted on neuroinflammation associated with the mTOR signaling pathway and the application of anti-inflammatory agents in epilepsy with different clinical features.This article reviews the role of the mTOR signaling pathway in neuroinflammation and the impact of their interactions on the development and progression of epilepsy,in order to provide new ideas for identifying effective therapeutic targets for epilepsy.