miR-330-3p/LHX6轴对子宫内膜癌细胞增殖、迁移和侵袭的影响OA

Objective To explore the effect of miR-330-3p on proliferation,migration,and invasion of endometrial cancer by targeting LIM homeobox 6(LHX6).Methods The clinical sig-nificance of miR-330-3p and LHX6 in endometrial cancer was analyzed by TCGA database.The binding site between miR-330-3p and LHX6 was predicted by Starbase and was then valida-ted.HEC108 and Ishikawa cell lines with miR-330-3p overexpression or miR-330-3p/LHX6 overex-pression were constructed to observe cells proliferation,migration and invasion.The xenograft nude mice model with miR-330-3p overexpressed HEC108 cells were constructed to observe the growth of transplanted tumors.Results The expression level of miR-330-3p was increased,while the expres-sion level of LHX6 was decreased in endometrial cancer tissues,and miR-330-3p could inhibit the expression of LHX6.Overexpression of miR-330-3p could promote the proliferation,migration and invasion of HEC108 and Ishikawa cells and the growth of transplanted tumors.Overexpression of LHX6 could partially reverse the effect of miR-330-3p overexpression in cells.Conclusion miR-330-3p can promote proliferation,migration and invasion of endometrial cancer by inhibiting the ex-pression of LHX6.