HBV合并甲状腺乳头状癌的临床病理学特征OA

Objective To investigate the clinicopathological characteristics of patients with papillary thyroid car-cinoma(PTC)concurrent with hepatitis B virus(HBV)infection.Methods Clinical data and pathological reports of 14 patients diagnosed with HBV-positive PTC from January 2019 to June 2025 were retrospectively collected.Histopatholog-ical morphology was analyzed,and immunohistochemical markers were evaluated to characterize tumor phenotypes.Results The male-to-female ratio was 1.5∶1,with ages ranging from 30-60 years(median 45 years).Disease re-mained stable after surgical resection and levothyroxine therapy.Tumor tissues showed strong expression of CK19 and Ga-lectin-3,positivity for BRAF V600E,and absent or reduced expression of TPO and CD56.HBcAg,HBsAg,and AFP were not expressed in tumor samples.Compared with typical PTC patients,HBV-positive PTC patients demonstrated a higher likelihood of metastatic calcification involving the tumor capsule.Conclusion HBV-associated PTC occurs more frequently in men and predominantly affects middle-aged to older adults,with earlier onset in males.Lesions are mainly unilateral and often present as micro-PTC.The immunophenotype is characterized by expression of CK19,Galectin-3,and BRAF V600E,with loss or reduction of CD56 and TPO and absence of HBV antigens and AFP.HBV-positive PTC exhibits a higher probability of metastatic calcification extending to the capsule than conventional PTC.