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痔切除术后肛缘水肿风险模型的构建与验证OA

Development and validation of a risk prediction model for perianal edema following hemor-rhoidectomy

中文摘要英文摘要

目的 分析痔切除术后发生肛缘水肿的危险因素,构建用于预测该并发症的列线图预测模型,并对模型性能进行验证.方法 回顾性分析2023年3月至2025年4月皖南医学院附属宣城医院接受痔切除术患者的临床资料,通过LASSO回归模型和多因素Logistic回归分析筛选痔切除术后发生肛缘水肿的独立危险因素,并构建列线图模型.采用受试者工作特征曲线、Hosmer-Lemeshow检验、Bootstrap方法、校准曲线、决策曲线分析对预测模型性能进行评估.结果 共纳入333例患者,根据术后是否发生肛缘水肿将患者分为无肛缘水肿组(n=178)和肛缘水肿组(n=155).结果 显示,女性、环状混合痔、未采用中药熏洗治疗、围手术期使用抗生素以及术后排便情况异常是痔切除术后发生肛缘水肿的独立危险因素,采用外剥内扎术联合自动弹力线套扎术的手术方式为保护因素.列线图模型的AUC为0.883(95%CI:0.848~0.918),校准曲线、决策曲线分析及临床影响曲线均证实其准确性和实用性.结论 本研究建立并验证了痔切除术后肛缘水肿的预测模型,该模型效能良好,可协助临床医师进行术前风险评估,实施早期针对性的干预,降低痔切除术后肛缘水肿的发生率.

Objectives To analyze the risk factors for perianal edema following hemorrhoidectomy,construct a nomogram prediction model for forecasting this complication,and validate the model's performance.Methods Clinical data of pa-tients who underwent hemorrhoidectomy at the Affiliated Xuancheng Hospital of Wannan Medical College from March 2023 to April 2025 were retrospectively analyzed.Independent risk factors for post-hemorrhoidectomy perianal edema were screened using LASSO regression and multivariate logistic regression analysis,based on which a nomogram prediction model was constructed.The model's performance was evaluated using the receiver operating characteristic curve,Hosmer-Lemeshow test,Bootstrap method,calibration curve,and decision curve analysis(DCA).Results A total of 333 patients were included and divided into a non-edema group(n=178)and an edema group(n=155)based on the occurrence of postoperative perianal edema.The results showed that female patients,circumferential mixed hemorrhoids,absence of tradi-tional Chinese medicine fumigation and washing therapy,perioperative antibiotic use,and abnormal postoperative defeca-tion were independent risk factors for perianal edema after hemorrhoidectomy.The surgical approach of Milligan-Morgan hemorrhoidectomy combined with automatic elastic band ligation was identified as a protective factor.The area under the curve for the nomogram model was 0.883(95%CI:0.848-0.918).Calibration curves,DCA,and clinical impact curves all con-firmed the model's accuracy and clinical utility.Conclusion This study developed and validated a prediction model for perianal edema following hemorrhoidectomy.The model demonstrates good performance and can assist clinicians in preop-erative risk assessment,enabling early targeted interventions to reduce the incidence of this complication.

陈银;赵世明

皖南医学院附属宣城医院肛肠外科 安徽 宣城 242000皖南医学院附属宣城医院肛肠外科 安徽 宣城 242000

医药卫生

肛缘水肿痔切除术列线图预测模型危险因素

perianal edemahemorrhoidectomynomogramprediction modelrisk factors

《结直肠肛门外科》 2026 (1)

74-82,9

10.19668/j.cnki.issn1674-0491.2026.01.011

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