基于磁共振评价金匮肾气丸汤方治疗变应性鼻炎疗效研究OA
Evaluation of Therapeutic Effect of Jingui Shenqi Pills Decoction on Allergic Rhinitis Based on MRI
目的:观察金匮肾气丸汤方治疗肾阳不足型变应性鼻炎的临床疗效,并探索运用磁共振评价治疗效果.方法:选取2022年1月至2022年12月成都中医药大学附属医院耳鼻咽喉科收治的50例肾阳不足型变应性鼻炎患者,按照随机数字表法分为试验组与对照组,每组各25例,试验组给予金匮肾气丸免煎剂治疗,对照组给予糠酸莫米松鼻喷雾剂联合依巴斯汀片治疗,疗程均为3周.比较两组的鼻结膜炎生活质量问卷调查(RQLQ)量表评分、中医症候量表评分和磁共振鼻部检查结果.结果:1.与治疗前相比较,两组患者治疗后RQLQ量表评分均降低(P<0.01);试验组和对照组在降低RQLQ总评分方面差异无统计学意义(P>0.05).2.与治疗前相比较,两组患者治疗后自拟中医症候量表总评分均下降(P<0.01),且试验组评分低于对照组(P<0.05).3.与治疗前相比较,两组患者治疗后磁共振鼻部体征均有改善(P<0.05),治疗后组间比较两组差异无统计学意义(P>0.05).4.试验组总有效率92%,对照组总有效率96%,差异无统计学意义(P>0.05).结论:1.金匮肾气丸汤方与西药均可有效治疗肾阳不足型变应性鼻炎,可显著改善患者临床症状、生活质量及鼻部体征,两者总体疗效相仿,但在改善总体症状、鼻塞症状及中医症候方面,试验组疗效更佳.2.运用磁共振评价中医药治疗变应性鼻炎疗效的优势作用不明显,有待进一步研究.
Objective:To observe the clinical efficacy of Jingui Shenqi Pills decoction in the treatment of allergic rhinitis with deficien-cy of Kidney Yang,and to explore the use of MRI to evaluate the treatment effect.Methods:From January 2022 to December 2022,fifty patients with allergic rhinitis of the Kidney-Yang deficiency type admitted to the department of otorhinolaryngology of the affiliated hospital of chengdu university of traditional chinese medicine were selected and divided into a test group and a control group according to the random number table method,with 25 cases in each group.The test group was given Jingui Shenqi Pills decoction,and the con-trol group was given Mometasone Furoate Aqueous Nasal Spray combined with Ebastine tablets.The treatment course of both groups was 3 weeks.RQLQ score,TCM syndrome scale score and MRI nasal examination results of the two groups before and after treatment were compared.Results:1.Compared with the pre-treatment period,the scores of the RQLQ scales were significantly lower in both groups after treatment(P<0.01);the difference between the test and control group in reducing the RQLQ scores was not statistically signifi-cant(P>0.05).2.Compared with the pre-treatment period,the total scores of the self-proposed TCM symptom scale decreased in both groups after treatment(P<0.01),and the test group was more effective than the control group in improving the symptoms of the Kidney-Yang deficiency type of AR patients(P<0.05).3.Compared with the pre-treatment period,MRI nasal signs improved in both groups after treatment(P<0.05);however,there was no statistically significant difference between the test group and the control group(P>0.05).4.The total effective rate was compared,the total effective rate of the test group was 92%,and the total effective rate of the control group was 96%,and the difference was not statistically significant(P>0.05).Conclusions:1.Both the Jingui Shenqi Pills decoction and western medicine can effectively treat allergic rhinitis of the Kidney-Yang deficiency.They can improve the clinical symptoms,quality of life,and nasal signs of the patients.However,the test group was more effective in improving overall symptoms,nasal congestion symptoms and TCM symptoms.2.The superior role of using MRI to evaluate the efficacy of Chinese medi-cine in the treatment of allergic rhinitis is not obvious and needs further study.
张明星;雷媛;张勤修
成都中医药大学 临床医学院,四川成都 610032||成都中医药大学附属医院,四川成都 610032乐山市中医院耳鼻咽喉科,四川乐山 614000成都中医药大学附属医院,四川成都 610032
医药卫生
金匮肾气丸变应性鼻炎肾阳不足鼻结膜炎生活质量问卷调查磁共振疗效研究
Jingui Shenqi PillsAllergic rhinitisKidney-Yang deficiencyRQLQMRIEfficacy observation
《成都中医药大学学报》 2026 (2)
49-53,5
四川省中医药管理局项目(2021MS052)
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