从"土壅木郁,精浊逆化"理论探讨加味茱萸丸治疗高脂血症的理论机制及现代药理基础OA

Based on the correspondence between traditional Chinese medicine(TCM)theories of"Fat turbidity"(Gao Zhuo)and"Blood turbidity"(Xue Zhuo)and the pathology of hyperlipidemia,this paper proposes the core pathogenesis:"Earth Congestion and Wood Stagnation(Tu Yong Mu Yu),with turbid essence undergoing reverse transformation."Dietary accumulation and damp obstruc-tion lead to"Earth Congestion"(Soil Stagnation),triggering Qi stagnation,mixture of clear and turbid substances,and emotional"depression"(Yu).This subsequently obstructs the Liver's dredging function.Liver depression causes abnormal transformation of nu-trients,which then combines with phlegm-dampness and stasis-heat to form a viscous,foul,and toxic"turbid Essence"(Zhuo Jing).This pathogenic substance follows disordered Qi movement to cause disease.To address this pathogenesis,the study developed the compound Baizhu Jiawei Zhuyu Pill(Atractylodes-Coptis-Evodia Pill)by adding Baizhu(White Atractylodes Rhizome),Shanzha(Hawthorn),and Laifuzi(Radish seed)to the foundational Evodia Pill.The formula employs:Baizhu(Monarch Herb)to unblock the intestines,fortify the spleen,and break"Earth Congestion";Huanglian(Coptis)and Wuzhuyu(Evodia,Assistant Herbs)to regulate liver-spleen Qi dynamics;Shanzha and Laifuzi(Courier Herbs)to invigorate blood,dissipate stasis,downbear Qi,and free the Fu organs.Collectively,providing an innovative treatment protocol for HLP prevention that integrates TCM and Western medical character-istics.