基于"微生物-肠-脑轴"探讨"上下交损,当治其中"在肿瘤相关性抑郁治疗中的应用OA

Cancer-related depression(CRD)refers to a pathological emotional state that emerges during cancer diagnosis and treatment.The"microbiome-gut-brain axis"(MGBA)reveals a complex bidirectional network connecting the brain,gut,and gut microbiota.Gut microbiota has become a key pathological marker of depression and a novel target for treating MGBA-related disorders.The principle of"treating the middle when both upper and lower impaired"addresses complex pathogenesis involving mutual impairment between upper and lower body regions,emphasizing the middle jiao as the pivot of qi movement."Mutual impairment of the upper and lower"is central to the pathogenesis of depression,and CRD exhibits such complexity with multi-organ involvement,particularly the liver,spleen,and heart.For CRD patients,the principle advocates"regulating the middle jiao"as the core approach—unblocking the middle region and restoring the qi movement pivot.Clinical applications include soothing the liver and relieving depression,smoothing the pivot,resolving phlegm and relieving depression,enhancing the function of transportation and transformation,and nourishing the heart,spleen and brain.A clinical case is included to illustrate the application of this principle in CRD.