老年冠心病伴焦虑抑郁的病机与治法探撷OA
Pathogenesis and treatment of coronary heart disease with anxiety and depression in older adults
冠心病伴焦虑抑郁是现代老年心血管疾病群体中多发的双心疾病,现有治疗手段难以同时改善临床双心症状和有效延缓或逆转冠心病病程,导致患者生存质量和预后受到严重影响.本文根据中医整体观念和《黄帝内经》等经典理论,结合团队研究和临证经验,通过"肾-心-脉-神"视角系统梳理肾、心、脉络在形质结构和机体气血津液代谢等方面的生理联系,并进一步阐释其在神志调节功能上的相互作用.认为肾元耗损、心气虚滞、精神失振是老年冠心病伴焦虑抑郁的发病根源;精亏血少、心脉凝涩、神失藏舍是病机演变的中间环节,进而诱生虚热、灼脉冲心、神躁失宁,导致疾病进展;最终形成停痰闭瘀、壅塞脉络、蒙蔽心神的病理状态,引发病情恶化.在此基础上提出分期治疗方案:早期偏抑郁者,宜滋肾益气、宣阳宽郁以行神,予还少丹合分心气饮、理郁升陷汤;早期偏焦虑者,宜精生血、和营通脉以荣神,予首乌延寿丹合茯苓补心汤、丹参饮;进展期宜涵阳降火、宁心清脉以安神,予安神丸合连茹绛复汤;加重期宜消痰逐瘀、涤脉开闭以醒神,分别予加味导痰汤合莲子清心饮、大黄䗪虫丸或抵当汤.本文围绕"肾-心-脉-神"视角展开研究,旨在为中医药防治老年冠心病伴焦虑抑郁提供新的思路与借鉴.
Coronary heart disease with anxiety and depression is a prevalent psycho-cardiological disease among the contemporary older adults with cardiovascular disease.Existing treatment method face challenges in simultaneously improving the clinical psycho-cardiological symptoms and delaying or reversing the course of coronary heart disease,resulting in a serious impact on the quality of life and prognosis of patients.Based on the overall concept of traditional Chinese medicine and classic theories such as the Huangdi Neijing,combined with team research and clinical experience,this paper systematically examines the physiological relationships among the kidney,heart,and vessels.The perspective of"kidney-heart-vessels-spirit"elucidates their synergistic interactions across multiple dimensions,including anatomical structure and the metabolism of body fluids,qi,and blood,and further explains their interactive roles in the regulation of mental functions.The pathogenesis of coronary heart disease with anxiety and depression in the older adults originates from kidney essence consumption,heart qi deficiency and stagnation,and loss of mental vitality.The intermediate stage involves the lack of essence and blood,stiff and astringent heart vessels,and loss of mind are intermediately linked.This leads to progression characterized by endogenous deficiency heat,burning pulse heart,and disorientation of the spirit.Ultimately,deterioration is caused by phlegm retention and blood stasis causing vascular obstruction and obscuration of the mind.According to the above pathogenesis,a specific staging treatment plan is proposed:for the early depression-dominant stage,Huanshao Elixir,combined with Fenxinqi Beverage and Liyu Shengxian Decoction,should be used to nourish the kidney and replenish qi,thereby facilitating yang circulation and alleviating constraint to regulate the spirit;for the early anxiety-dominant stage,Shouwu Yanshou Elixir,combined with Fuling Buxin Decoction and Danshen Beverage,is used to nourish essence and generate blood,thereby harmonizing ying and unblocking meridians to nourish the spirit.During the progressive stage,Anshen Pill,combined with Lianru Jiangfu Decoction,is used to reduce floating yang and downbear fire,tranquilize the heart,and clear the vessels to calm the spirit.In the aggravated stage,Modified Daotan Decoction,combined with Lianzi Qingxin Beverage,Dahuang Zhechong Elixir or Didang Decoction,is used to eliminate phlegm and remove blood stasis,thereby clearing the channels and regulating opening and closing to awaken the spirit.Based on the perspective of"kidney-heart-vessels-spirit",this approach aims to provide a new reference for the prevention and treatment of coronary heart disease complicated by anxiety and depression in the older adults.
蔡泳源;严诏琦;王秋铭;耿金珠;任甜甜;陈佳美;刘志明;刘如秀
中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053中国中医科学院广安门医院 北京 100053
医药卫生
老年冠心病焦虑抑郁肾-心-脉-神
older adultscoronary heart diseaseanxietydepressionkidney-heart-vessels-spirit
《北京中医药大学学报》 2026 (3)
311-318,8
北京市中医管理局北京中医药薪火传承"新3+3"工程项目(No.2023-SZ-F-06,No.2023-SZ-G-02)中央高水平中医医院临床科研业务费资助项目(No.HLCMHPP2023053)中国中医科学院学部委员学术传承与传播专项(No.CI2022E012XB)中国中医科学院研究生科技创新项目(No.KC2025014) Beijing Traditional Chinese Medicine Firewood Inheritance"New 3+3 project"Station Construction Project by Beijing Administration of Traditional Chinese Medicine(Nos.2023-SZ-F-06 and No.2023-SZ-G-02)
评论