呼吸吐纳操在慢性阻塞性肺疾病急性加重期患者早期肺康复中的效果评价OA

Objective To evaluate the effectiveness of exhalation-inhalation exercise on early pulmonary rehabi-litation for patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 120 participants with AECOPD were randomly divided into a treatment group and a control group,with 60 partici-pants in each group.The control group treated with conventional western medicine,while the treatment group received exhalation-inhalation exercise training on the basis of conventional western medicine treatment,with 30 minutes per session and 5 sessions per week.The course of treatment for both groups was 12 weeks.The primary outcome was the 6-minute walking distance(6MWD).The secondary outcomes included pulmonary function indexes including forced expiratory volume in one second/forced vital capacity(FEV1/FVC),percentage of predicted forced expiratory volume in one second(FEV1％)and percentage of predicted forced vital capacity(FVC％),St.George's Respiratory Questionnaire(SGRQ)score,modified Medical Research Council(mMRC)dyspnea scale score,COPD assessment test(CAT)score,hospital anxiety and depression scale-anxiety subscale[HADS(A)]score,and hospital anxiety and depression scale-depression subscale[HADS(D)]score.Meanwhile,safety of all participants was recorded and assessed.Results During the treatment,12 participants dropped out from both the treatment group and the control group,with 48 participants in each group finally included in the analysis.The 6MWD of both groups after treatment was higher than that before treatment,and the 6MWD of the treatment group was higher than that of the control group(P＜0.05 or P＜0.01).After treatment,the SGRQ score,mMRC score and CAT score of the treatment group were lower than those before treatment,while FEV1％,FVC％and FEV1/FVC were higher than those before treatment(P＜0.05).Moreover,after treatment,the FEV1/FVC of the treatment group was higher than that of the control group,while the SGRQ score,mMRC score and CAT score were lower than those of the control group(P＜0.05 or P＜0.01).There was no statistically significant difference in pulmonary function indexes,SGRQ score,mMRC score and CAT score after treatment in the control group(P＞0.05).No statistically significant difference was observed in HADS(A)score and HADS(D)score after treatment within and between groups(P＞0.05).The incidence of adverse reactions in the treatment group was 6.25％(3/48),and 0 in the control group,with no statistically signifi-cant difference between groups(P＞0.05).Conclusion Exhalation-inhalation exercise for patients with AECOPD in early pulmonary rehabilitation can improve patients' exercise tole-rance,quality of life,clinical symptoms and pulmo-nary function,with good safety.