胃癌前病变中医药防治研究现状及展望OA

Traditional Chinese medicine(TCM),through its multi-target and systematic regulatory effects,has demonstrated unique advantages in the treatment of gastric precancerous lesions(GPL).At present,TCM theoretical research on GPL is mainly reflected in three aspects,the integration of macroscopic syndrome differentiation,the inflammation-carcinoma transformation mechanism,as well as the systematization and scientization of theoretical inheritance from famous TCM practitioners.High-quality evidence-based research findings serve as the foundation for clinical practice guidelines on GPL,and TCM has gained international academic recognition in the field of GPL pre-vention and treatment.Research on TCM mechanisms has yielded a series of important outcomes in the aspects of sig-naling pathways,gene expression regulation,cellular epigenetics,histone modification,and intestinal microecology.It is proposed that future research on GPL should focus on four key directions,establishing multi-omics data,explor-ing targeted intervention strategies on key regulatory nodes,advancing the standardization process of integrated tradi-tional Chinese and western medicine prevention and treatment technologies,and constructing stratified screening and intervention platforms.The in-depth integration of TCM microcosmic mechanism of action with its macroscopic syn-drome differentiation and treatment system,coupled with interdisciplinary research,will provide valuable references for the clinical treatment and scientific research of GPL.