功能性消化不良中西医诊疗及机制研究概况OA

Functional dyspepsia(FD)is a prioritized disease category where traditional Chinese medicine(TCM)demonstrates distinct therapeutic advantages.The current western medicine treatment for FD is mainly based on pro-ton pump inhibitors and prokinetic agents,with digestive enzymes,probiotics and antidepressants serving as adju-vant medication,yet such therapies still have certain limitations.TCM treatment for FD includes oral administration of Chinese herbal formulas and Chinese patent medicines,as well as external TCM therapies such as acupuncture and moxibustion,acupoint application,hot medicinal compress therapy,rubbing with ointment,medicinal iontophoresis,auricular acupoint therapy and tui na(Chinese medical massage).The combined treatment of FD with integrated TCM and western medicine can significantly improve clinical effectiveness and reduce adverse reactions.The common mechanisms underlying the therapeutic effects of both TCM and western medicine revolve around the core pathological processes of FD,mainly focusing on restoring gastrointestinal motility,regulating the levels of brain-gut peptides,modulating intestinal microecology,and ameliorating inflammatory status.The differential mechanisms lie in the pre-cise targeting feature of western medicine versus the holistic-regulating and multi-target characteristics of TCM,and the two approaches exert a synergistic effect to enhance efficacy.This paper proposes to leverage the advantages of TCM in holistic regulation and the strengths of western medicine in targeted treatment,so as to provide personalized and comprehensive treatment regimens for FD patients.