代谢相关脂肪性肝病的中医诊疗研究现状及展望OA

The pathogenesis of metabolic dysfunction-associated steatotic liver disease(MASLD)is fundamentally rooted in spleen deficiency and is closely associated with phlegm turbidity,damp-heat and blood stasis.Clinically,liver constraint with spleen deficiency and internal retention of damp turbidity represent the predominant traditional Chinese medicine(TCM)syndrome patterns.Researches have indicated intrinsic connections between the syndrome patterns and biological indicators such as gut microbiota and metabolic profiles.Regarding treatment,classical famous formulas,modern empirical formulas,and newly developed TCM drugs show positive effects in regulating glucose and lipid metabolism,improving insulin resistance,and alleviating metabolic inflammation,exhibiting multi-target mech-anisms of action;acupuncture and other external therapies also provide adjunctive value.Nevertheless,current re-searches still have limitations such as the lack of high-quality clinical evidence and insufficient systematic elucidation of the uncerlying mechanisms.Future efforts should focus on conducting high-quality TCM clinical trials with hard endpoint outcomes such as hepatic histology outcomes,and utilizing modern technologies like multi-omics to elucidate TCM's mechanisms of action,thereby advancing the position of TCM as a first-line therapeutic strategy for MASLD.