黄芪汤固体饮料制备工艺研究OA

Objective:Develop a solid beverage to alleviate constipation based on the classic formula Huangqi Decoction,and optimize the preparation process.Methods:A single-factor combined response surface methodology was employed to investigate the interaction effects of three factors including solid-to-liquid ratio,number of decoctions,and decoction time,and total flavonoids,total saponins,and total polysaccharides were as response variables.This approach determined the optimal extraction process,with the content of total flavonoids,total saponins and total polysaccharides in the extract were measured by ultraviolet spectrophotometry.Using powder collection efficiency as the metric,a single-factor orthogonal design was employed to evaluate spray-drying processes for extraction solutions.Single-factor experiments screened excipients,with comprehensive scoring based on flowability,moisture absorption rate,solubility and sensory evaluation to determine the optimal formulation.Results:The optimal extraction process for Astragalus membranaceus decoction involves a solid-to-liquid ratio of 1∶15(g∶mL),with three decoction cycles of 80 minutes each.Spray drying parameters:inlet air temperature 180℃,fan frequency 65 Hz,feed flow rate 11 rpm.The optimal formulation for solid beverages:lactose as excipient with a drug-to-excipient ratio of 1∶0.7(g∶g)achieved the highest overall score.Conclusion:The preparation process of Astragalus Solid Beverage is stable,with excellent solubility and flowability,making it convenient for carrying and storage.