针药结合干预帕金森前驱期疾病易感状态的机制研究OA
Research on the Mechanism of Acupuncture Combined with Traditional Chinese Medicine in Intervening the Susceptibility State of Parkinson's Disease in Prodromal Stage
目的:探究针药结合干预帕金森前驱期疾病易感状态的机制.方法:采用ELISA检测大鼠纹状体DA含量、大鼠黑质、海马、嗅球、结肠的TLR2 水平;采用行为学评估大鼠情志相关的行为学指标,蔗糖溶液偏好率、鼠尾悬挂静止时间;采用行为学评估大鼠睡眠相关的行为学指标,睡眠潜伏期、睡眠持续时间.结果:随着帕金森前驱期疾病易感状态的逐渐进展,DA含量逐渐减少,黑质、海马、嗅球、结肠的TLR2 水平逐渐增加;针药结合治疗后,显著增加蔗糖溶液偏好率、降低鼠尾悬挂静止时间,缩短睡眠潜伏期、延长睡眠持续时间.结论:针药结合能够逆转帕金森前驱期疾病易感状态.
Objective:To explore the mechanism of acupuncture combined with traditional Chinese medicine intervention in the susceptible state of Parkinson's disease in the prodromal stage.Methods:DA content in the striatum of rats,TLR2 levels in the substantia nigra,hippocampus,olfactory bulb,and colon of rats were detected by ELISA;behavioral indicators related to emotional stress in rats were evaluated,including sucrose solution preference rate and tail suspension immobility time;behavioral indicators related to sleep in rats were evaluated,including sleep latency and sleep duration.Results:As the susceptible state of Parkinson's disease in the prodromal stage gradually progressed,DA content gradually decreased,and TLR2 levels in the substantia nigra,hippocampus,olfactory bulb,and colon gradually increased;after acupuncture-medicine combination treatment,the sucrose solution preference rate was significantly increased,the tail suspension immobility time was reduced,the sleep latency was shortened,and the sleep duration was prolonged.Conclusion:Acupuncture combined with traditional Chinese medicine can reverse the predisposition to Parkinson's disease in the prodromal stage.
徐珂;李元;胡丙成;张宇;白妍;王顺
黑龙江中医药大学·黑龙江 哈尔滨 150040哈尔滨医科大学附属第一医院·黑龙江 哈尔滨 150001黑龙江省中医药科学院·黑龙江 哈尔滨 150036黑龙江中医药大学·黑龙江 哈尔滨 150040黑龙江省中医药科学院·黑龙江 哈尔滨 150036黑龙江中医药大学·黑龙江 哈尔滨 150040
帕金森帕金森前驱期疾病易感状态情志应激针药结合
Parkinson's diseaseParkinson's prodromal stagedisease susceptibility stateemotional stressacupuncture combined with Traditional Chinese Medicine
《中国中医药科技》 2026 (1)
5-9,5
国家自然科学基金面上项目(82474664)
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