水光针注射致面部肉芽肿3例及文献复习OA

Objective To investigate the clinical features,treatment approaches and therapeutic effects of granuloma after mesotherapy injection.Methods Three patients with granuloma caused by mesotherapy injection who visited the dermatology outpatient department of Union Hospital,Tongji Medical College,Huazhong University of Science and Technology from 2023 to 2024 were reported.A combined treatment plan was adopted,with oral minocycline as the systemic anti-inflammatory treatment,and carbon dioxide fractional laser combined with triamcinolone acetonide wet compress for local treatment.After the nodules subsided,intense pulsed light and chemical peelings were used to treat pigmentation and telangiectasia.Results After outpatient treatment,the skin lesions of the 3 patients all improved.The facial papules subsided and flattened,leaving a few pigmented spots.Follow-up treatment was still continued to improve the pigmentation.Conclusion The extensive use of mesotherapy injections has also led to an increase in the number of adverse reactions,especially foreign body granulomas on the face.In addition to systemic anti-inflammatory treatment with antibiotics,local treatment is also very important.We used carbon dioxide fractional laser combined with triamcinolone wet compress,which has fewer side effects than intralesional corticosteroids and is not easy to cause local atrophy.After the nodules regressed,intense pulsed light therapy for pigmentation and telangiectasia could effectively further improve the skin lesions.