Ki-67高表达胃肠道间质瘤CT增强扫描特征影响因素分析OA

Objective:To investigate CT features associated with high Ki-67 expression in gastrointestinal stromal tumor(GIST)and to identify potential imaging influencing factors.Methods:The clinical and CT data of 191 GIST patients were collected.All patients were stratified into a high expression group(71 cases,Ki-67＞5%)and a low expression group(120 cases,Ki-67≤5%).Comparative analysis of CT qualitative and quantitative characteristics between the two groups was executed.Spearman correlation analysis was used to analyze the CT features related to the high Ki-67 expression.Binary logistic regression analysis was employed to ascertain the influencing factors associated with high Ki-67 expression in GIST.Results:Statistically significant differences were identified in tumor maximum and minimum diameters,risk grade,growth pattern,cystic degeneration,enhancement degree and rate in the portal venous phase between the two groups(all P＜0.05).These CT features exhibited a weak correlation with high Ki-67 expression(r=0.147-0.371).Logistic regression analysis revealed that intermediate/high risk grade,maximum diameter(＞5.85 cm),minimum diameter(＞2.95 cm),intraluminal growth pattern,cystic degeneration,enhancement degree(＞58.25 HU)and enhancement rate(＞1.73)in the portal venous phase were the independent influencing factors for high Ki-67 expression in GIST.Conclusions:Intermediate/high risk grade,maximum diameter(＞5.85 cm),minimum diameter(＞2.95 cm),intraluminal growth pattern,cystic degeneration,enhancement degree(＞58.25 HU)and enhancement rate(＞1.73)in the portal venous phase are the independent influencing factors for high Ki-67 expression in GIST.