参葛补肾胶囊联合喹硫平片治疗抑郁症患者的疗效及对睡眠质量和神经递质的影响OA
Efficacy of Shen Ge Bushen Capsules Combined with Quetiapine Tablets in the Treatment of Patients with Depression and Their Effects on Sleep Quality and Neurotransmitters
目的 探讨参葛补肾胶囊联合喹硫平片治疗抑郁症患者的疗效及对睡眠质量和神经递质的影响.方法 选取2024年 7 月至 2024 年 11 月乌鲁木齐市第四人民医院收治的 100 例抑郁症患者作为研究对象,按照随机数字表法分为观察组与对照组,各50 例.对照组采用喹硫平片治疗,观察组采用参葛补肾胶囊联合喹硫平片治疗.比较两组患者疗效、自杀意念自评量表(SIOSS)评分、睡眠脑电图参数及神经递质多巴胺(DA)、谷氨酸(Glu)、去甲肾上腺素(NE)、γ-氨基丁酸(GABA)、乙酰胆碱(ACh)及5-羟色胺(5-HT).结果 观察组治疗有效率明显高于对照组(P＜0.05);治疗前,两组乐观、绝望、掩饰、睡眠评分及SIOSS总分比较差异无统计学意义(P＞0.05);治疗后,观察组乐观、绝望、掩饰、睡眠评分及SIOSS总分明显低于对照组(P＜0.05);治疗前,两组觉醒次数、睡眠潜伏期、睡眠效率及觉醒时间比较差异无统计学意义(P＞0.05);治疗后,观察组睡眠效率明显高于对照组(P＜0.05),觉醒次数、睡眠潜伏期及觉醒时间明显低于对照组(P＜0.05);治疗前,两组DA、Glu、NE、GABA、ACh及 5-HT水平比较差异无统计学意义(P＞0.05);治疗后,观察组DA、NE、GABA、ACh及 5-HT水平明显高于对照组(P＜0.05),Glu水平明显低于对照组(P＜0.05);两组口干、震颤、头晕及恶心发生率比较差异无统计学意义(P＞0.05).结论 参葛补肾胶囊联合喹硫平片治疗抑郁症的效果确切,能明显降低自杀意念和改善睡眠质量,有效调节神经递质水平,且安全性良好.
Objective To explore the efficacy of Shen Ge Bushen Capsules combined with quetiapine tablets in the treatment of patients with depression and their effects on sleep quality and neurotransmitters.Methods A total of 100 patients with depression who were admitted to the Fourth People's Hospital of Urumqi from July 2024 to November 2024 were selected as the research subjects.They were randomly divided into the observation group and the control group,with 50 cases in each group.The control group was treated with quetiapine tablets,while the observation group was treated with Shenge Bu Xin Capsules combined with quetiapine tablets.The therapeutic effects,Self-Rating Impulse Control Scale(SIOSS)scores,sleep electroencephalogram parameters,and neurotransmitter indicators of the two groups were compared.Results The effective rate of treatment in the observation group was significantly higher than that in the control group(P＜0.05);before treatment,there was no statistically significant difference in the scores of optimism,hopelessness,concealment,sleep,and the total score of SIOSS between the two groups(P＞0.05);after treatment,the scores of optimism,hopelessness,concealment,sleep,and the total score of SIOSS in the observation group were significantly lower than those in the control group(P＜0.05);before treatment,there was no statistically significant difference in the number of awakenings,sleep latency,sleep efficiency,and awakening time between the two groups(P＞0.05);after treatment,the sleep efficiency of the observation group was significantly higher than that of the control group(P＜0.05),and the number of awakenings,sleep latency,and awakening time of the observation group were significantly lower than those of the control group(P＜0.05);before treatment,there was no statistically significant difference in the levels of dopamine(DA),glutamate(Glu),norepinephrine(NE),γ-aminobutyric acid(GABA),acetylcholine(Ach),and 5-hydroxytryptamine(5-HT)between the two groups(P＞0.05);after treatment,the levels of DA,NE,GABA,Ach,and 5-HT in the observation group were significantly higher than those in the control group(P＜0.05),and the level of Glu was significantly lower than that of the control group(P＜0.05);there was no statistically significant difference in the incidence of dry mouth,tremor,dizziness,and nausea between the two groups(P＞0.05).Conclusion The treatment of depression with Shen Ge Bu Shen Capsules combined with Quisapride Tablets is highly effective.It can significantly reduce suicidal thoughts and improve sleep quality,effectively regulate neurotransmitter levels,and has good safety.
邹钰婷
乌鲁木齐市第四人民医院药剂科,乌鲁木齐 830000
医药卫生
参葛补肾胶囊喹硫平片抑郁症自杀意念睡眠脑电图神经递质
Shen Ge Bu Shen CapsulesQuetiapine tabletsDepressionSuicidal ideationSleepElectroencephalogramNeurotransmitters
《中国药物经济学》 2026 (1)
89-93,5
乌鲁木齐市卫生健康委科技计划项目(202317)
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