血压变异性升高大鼠模型构建研究进展OA
Research progress on construction of rat models with elevated blood pressure variability
血压变异性升高对高血压人群的心脏、脑、肾、血管等靶器官损害的发生与发展具有重要的促进作用,控制血压变异性是降低高血压患者心血管事件发生率和病死率的有效方法.本文综述血压变异性升高大鼠模型的构建方法和模型特点,以期为血压变异性升高的实验研究提供动物模型参考.
The increased of blood pressure variability(BPV)plays important role in the occurrence and development of target organs such as heart,brain,kidney and blood vessel damage in hypertensive population,controlling BPV is an effective method to reduce the incidence of cardiovascular events and mortality in patients with hypertensive.Through literature mining and collation,this article reviews the construction methods and model characteristics of rat models with increased BPV,in order to provide references for experimental research on BPV elevation.
杜丽东;杜玉姣;石磊;翟婉莹;杨志军;赵英;郭娇宏;吴国泰
甘肃中医药大学药学院,兰州 730000||甘肃中医药大学陇药产业创新研究院,兰州 730000甘肃中医药大学药学院,兰州 730000甘肃中医药大学药学院,兰州 730000甘肃中医药大学药学院,兰州 730000甘肃中医药大学药学院,兰州 730000甘肃中医药大学基础医学院,兰州 730000甘肃省平凉市第二人民医院心血管内科,甘肃平凉 744000甘肃中医药大学药学院,兰州 730000||甘肃中医药大学陇药产业创新研究院,兰州 730000
生物科学
高血压血压变异性大鼠模型研究进展
hypertensionblood pressure variabilityrat modelresearch progress
《中国实验动物学报》 2026 (2)
257-263,7
甘肃省高等学校创新基金项目(2021A-080),甘肃省教育科技创新项目(2022A-068),甘肃省中药药理与毒理重点实验室开放基金项目(ZDSYS-KJ-2024-003).Funded by Gansu Province Higher Education Innovation Project(2021A-080),Gansu Province Education Technology Innovation Project(2022A-068),Open Fund Project of Key Laboratory of Traditional Chinese Medicine Pharmacology and Toxicology in Gansu Province(ZDSYS-KJ-2024-003).
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