递送西他列汀的分段式聚合物微针的成型工艺及扩散性能表征OA
Fabrication technology and transdermal diffusion performance of segmented polymer microneedles for sitagliptin delivery
提出了一种递送西他列汀的分段式聚合物微针,设计了递送西他列汀的分段式聚合物微针及其阵列结构,在对其形貌尺寸以及力学性能进行系统表征的基础上,进一步探究了其力学特性与透皮药物释放性能.结果表明,递送西他列汀的分段式聚合物微针成型效果良好,具有能够穿刺皮肤角质层的力学性能;透皮药物扩散性能测试结果显示递送西他列汀的分段式聚合物微针在2 min释放药物搭载量的72.3%,10 min释放药物搭载量的97.1%,展现出良好药物释放效能,为肥胖症治疗提供了一种新的有效方法.
This study presents the design,fabrication,and characterization of segmented polymer microneedles for the transder-mal delivery of sitagliptin.The microneedle geometry and array architecture were specifically engineered to enable efficient drug administration.Comprehensive evaluations of morphology,dimensional accuracy,and mechanical properties confirmed that the fabricated microneedles possess sufficient structural integrity to reliably penetrate the stratum corneum.In vitro transdermal dif-fusion tests demonstrated rapid and sustained drug release:72.3%of the loaded sitagliptin was released within 2 min,and cu-mulative release reached 97.1%by 10 min.These results highlight the excellent drug release kinetics and potential clinical utili-ty of the developed system.Given sitagliptin's therapeutic relevance in metabolic disorders,this microneedle platform offers a promising,minimally invasive strategy for the management of obesity and related conditions.
康晓雅;庄俭;霍则军;张浩琳;孟秀丽;胡晓青;朱敬先;原福贞;高强;彭荣梅
北京化工大学机电工程学院,塑料机械及塑料工程研究所实验室,北京 100029北京化工大学机电工程学院,塑料机械及塑料工程研究所实验室,北京 100029北京大学第三医院,中医科,北京 100191北京大学第三医院,中医科,北京 100191北京大学第三医院,中医科,北京 100191北京大学第三医院,中医科,北京 100191北京大学第三医院,中医科,北京 100191北京大学第三医院,中医科,北京 100191北京化工大学机电工程学院,塑料机械及塑料工程研究所实验室,北京 100029北京大学第三医院,中医科,北京 100191
化学化工
药物释放分段式结构肥胖症微针阵列西他列汀
drug releasesegmented structureobesitymicroneedle arraysitagliptin
《中国塑料》 2026 (3)
42-47,6
北京大学第三医院创新转化基金/海淀转化专项"计划(HDCXZHKC2023208)北京大学第三医院创新与转型基金(BYSYZH-KC2023112)北医三院创新转化基金项目(BYSYZHZB202521)
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