基于SNP芯片揭示安庆六白猪遗传多样性和选择特征OA

In order to reveal the genetic diversity,population structure and selection differences between Anqing Six-end-white pig and Landrace pig populations,this study evaluated the proportion of polymorphic marker(PN),observed heterozygosity(HO),expected het-erozygosity(HE)and minor allele frequency(MAF)of the two populations based on the genomic SNP location information,and identified the selection differences between the two populations based on the methods of fixation index(FST)and nucleotide diversity ratios(θπ ratio).The results showed that the PN of Anqing Six-end-white pigs and Landrace pigs were 0.897 5 and 0.836 9,their HO was 0.349 9 and 0.333 8,their HE was 0.336 2 and 0.327 0,and their MAF were 0.251 2 and 0.245 8,respectively.The genetic diversity of Anqing Six-end-white pigs was higher than that of Landrace pigs.The phylogenetic tree and PCA analysis indicated significant genetic differentiation between the two populations.Combining the results of FST and θπ ratio selection signal analyses,a total of 540 selection regions were screened,accounting for 0.1041%of the porcine autosomal genome,including 59 candidate genes.Through gene function enrichment analy-sis,further screening showed that natriuretic peptide receptor 2(NPR2),annexin A11(ANXA11),and nuclear receptor coactivator 6(NCOA6)genes might be related to reproduction;myosin light chain 9(MYL9)and protein O-fucosyltransferase 1(POFUT1)genes might be related to muscle growth and development;lipid droplet associated hydrolase(LDAH),hydroxy acid oxidase 1(HOA1),neurotin(NNAT),and tumor protein p53 inducible nuclear protein 2(TP53INP2)might be related to fat deposition.This study provided a theoreti-cal support for the protection of germplasm resources,development and utilization of Anqing Six-end-white pigs.