基于文献的国内不同地区牛奶源大肠杆菌耐药性分析OA

In order to guide clinical administration in dairy farming and to control potential risk of bacterial antibiotic resistance(AMR),relevant literature published from 2008 to 2023 was retrieved,covering 28 articles,and data on the AMR of milk-derived Escherichia coli(E.coli)to 34 antibiotics in 20 provinces in China were pooled and analyzed.The results showed that theE.coli was highly resistant to cephalothin(53.63％),ampicillin(51.69％)and trimethoprim-sulfamethoxazole(45.37％),lower to levofloxacin(1.17％)and tobramycin(1.33％),but null to imipenem;based on the statistical analysis on the resistance to 8 antibiotics detected in all 7 provinces,it was found that the overall AMR rate was the highest in Xinjiang(62.01％),and the lowest in Inner Mongolia(11.07％);in accordance with the analysis of AMR to 3 antibiotics(tetracycline,gentamicin and ciprofloxacin)under specific monitoring in 20 provinces,the AMR rate significantly depended on different provinces,was the highest to tetracycline in Jilin(96.67％),to gentamicin in Shandong(72.27％),and to ciprofloxacin in Henan(73.66％),but none to all the 3 antibiotics was detected in Gansu province.In conclusion,the AMR of milk-derived E.coli was prominent with obvious regional characteristics,requiring the improvement of targeted regulation,prevention and control.