基于孟德尔随机化分析的肠道菌群和新生儿高胆红素血症因果关联研究OA
Study on the Causal Relationship Between Intestinal Flora and Neonatal Hyperbilirubinemia Based on Mendelian Randomization Analysis
目的 采用孟德尔随机化方法探讨肠道菌群和新生儿高胆红素血症之间的因果关联.方法 利用大样本全基因组关联性研究(GWAS)的汇总数据,选择与新生儿高胆红素血症密切关联的遗传位点作为工具变量,用逆方差加权法、MR-Egger回归、加权中位数、简单模型和加权模型做两样本孟德尔随机化分析,以评价肠道菌群和新生儿高胆红素血症之间的因果关系.结果 逆方差加权法分析显示双歧杆菌(OR=0.2733,95%CI:0.0918～0.8133)和阿德勒克罗伊茨菌(OR=0.2733,95%CI:2.0085～26.7286)与新生儿高胆红素血症有因果关联,MR-Egger回归、加权中位数、简单模型和加权模型与逆方差加权法结果一致.结论 双歧杆菌丰度与新生儿高胆红素血症发病风险之间存在负向因果关联.
Objective To explore the causal relationship between intestinal flora and neonatal hyperbilirubinemia by Mendelian randomization method.Methods Using the summary data of large sample genome-wide association study(GWAS),the genetic loci closely related to neonatal hyperbilirubinemia were selected as instrumental variables.Two-sample Mendelian randomization analysis was performed using inverse variance weighting method,MR-Egger regression,weighted median,simple model and weighted model to evaluate the causal relationship between intestinal flora and neonatal hyperbilirubinemia.Results The inverse variance weighting method showed that Bifidobacterium(OR=0.2733,95%CI:0.0918-0.8133)and Kreuzella adelbrueckii(OR=0.2733,95%CI:2.0085-26.7286)were causally associated with neonatal hyperbilirubinemia.The results of MR-Egger regression,weighted median,simple model and weighted model were consistent with those of inverse variance weighting method.Conclusion There is a negative causal relationship between the abundance of Bifidobacterium and the risk of neonatal hyperbilirubinemia.
孔德进;高阳
临沂市中心医院儿科,山东 临沂 276400临沂市中心医院儿科,山东 临沂 276400
医药卫生
肠道菌群新生儿高胆红素血症孟德尔随机化
Intestinal floraNeonatal hyperbilirubinemiaMendelian randomization
《医学信息》 2026 (5)
22-27,6
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