浆液性卵巢癌SFRP2和MORC2的表达及其预后意义OA

Objective To observe the expression of SFRP2 and MORC2 in serous ovarian cancer tissues,and analyze their correlation with clinicopathological significance and prognosis.Methods The pathological data of 58 pairs of serous ovarian cancer and adjacent normal tissues from 2019 to 2021 were collected.Immunohistochemistry(IHC)was used to detect the protein expression of SFRP2 and MORC2 in serous ovarian cancer and adjacent normal tissues.The relationship between the expression of SFRP2,MORC2 and the clinicopathological parameters,survival prognosis of patients was statistically analyzed.Results HE staining showed the characteristics of SOC:serous ovarian cancer formed a papillary shape,low-grade serous cancer showed small cancer cell atypia and few nuclear division;high-grade serous carcinoma with obvious cancer cell atypia,tumor giant cells and pathological mitosis were common.The IHC results showed that the positive expression rates of SFRP2 and MORC2 were significantly different between serous ovarian cancer and adjacent normal tissues(P<0.05).There were significant differences in the expression of SFRP2 and MORC2 in different FIGO stages of serous ovarian cancer(P<0.05).There were no significant differences in age,pathological grade and lymph node metastasis(P>0.05).The higher the expression level of SFRP2 and MORC2,the shorter the survival time of patients.Conclusion The expression levels of SFRP2 and MORC2 are increased in serous ovarian cancer,and the expression of SFRP2 and MORC2 may be related to FIGO stage and poor prognosis of serous ovarian cancer.