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视网膜色素变性并发性白内障围术期管理OA

Perioperative management of cataract surgery in patients with retinitis pigmentosa

中文摘要英文摘要

视网膜色素变性(retinitis pigmentosa,RP)是一种以进行性感光细胞及色素上皮功能丧失为共同表现的遗传性视网膜变性疾病.其眼底检查存在一系列特征性改变,包括骨细胞样色素沉着、视网膜血管变细以及视盘颜色蜡黄等.其临床表现包括夜盲、视力下降、进行性视野缺损、视网膜电流图(electroretinogram,ERG)显著异常或无波型等.白内障是RP患者最常见的并发症,多表现为晶状体后囊下混浊,对视力影响较大,需要手术治疗.然而,由于RP患者常伴有晶状体悬韧带松弛或离断、前房浅、房角狭窄等解剖学异常,易合并闭角型青光眼,因此该类患者的白内障手术难度大、并发症发生率高、视功能预后差且难以准确预测.本文系统性总结了RP并发性白内障患者的临床特点,并针对该类患者白内障手术的术前检查和评估、围术期手术并发症的防治、术后随访等方面进行综述,旨在为临床诊疗提供参考.

Retinitis pigmentosa(RP)is an inherited retinal degenerative disease.Typical fundus changes associated with RP are characterized by bone-spicule-shaped pigment deposits,attenuated retinal vessels,and a waxy-pale appearance of the optic nerve.These changes lead to a range of visual impairments,including night blindness,vision loss,progressive loss of the peripheral visual field.Cataract is one of the most frequently occurring complications in patients with RP.It typically presents posterior subcapsular opacification,which can severely affect vision and often necessitates surgical intervention.However,RP patients frequently exihibit anatomical abnormalities,such as zonular dialysis or dehiscence,a shallow anterior chamber,and a narrow anterior chamber angle.These abnormalities place them a higher risk of developing angle closure glaucoma.Performing phacoemulsification in these patients is highly challenging,as there is a high incidence of complications.Moreover,the prognosis for visual acuity is often poor and difficult to predict precisely.In this review,we provide a comprehensive summary of the clinical characteristics of RP patients.We also conduct a thorough review of the preoperative evaluation process,preventive strategies for surgical complications,and postoperative follow-up procedure for cataract patients with RP.Our aim is to offer practical guidance for clinical practice.

余玟璐;潘玉珂;袁浩睿;张佳晴;陈伟蓉;罗莉霞;谈旭华

中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州 510060中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州 510060中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州 510060中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州 510060中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州 510060中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州 510060中山大学中山眼科中心,眼病防治全国重点实验室,广东省眼科视觉科学重点实验室,广州 510060

医药卫生

视网膜色素变性白内障围术期超声乳化白内障吸除术

retinitis pigmentosacataractperioperative periodphacoemulsification

《眼科学报》 2026 (2)

123-132,10

国家自然科学基金(82571189,82571188)广东省自然科学基金(2025A1515012910)广州市重大疑难罕见病诊疗中心建设项目(2024MDRD05).This work was supported by the National Natural Science Funds of China(82571189,82571188)the Natural Science Foundation of Guangdong Province(2025A1515012910)Construction Project of Guangzhou Diagnosis and Treatment Center for Major,Difficult,and Rare Diseases(2024MDRD05).

10.12419/25041802

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