宋虎杰主任医师经验方解郁安神汤治疗出血性卒中后抑郁临床随机对照研究OA
A Controlled Clinical Study of Chief Physician Song Hujie's Experience Prescription Jieyu Anshen Decoction in the Treatment of Post-hemorrhagic Stroke Depression(Invited by Fan Xiaoxuan)
目的 观察宋虎杰主任医师经验方解郁安神汤治疗卒中后抑郁的临床效果及对生活质量和认知功能的改善情况.方法 选取 32 例西安中医脑病医院 2024 年全年收治的出血性卒中后抑郁患者,按照随机数字表法将各16 位患者随机分为治疗组和对照组.对照组给予常规对症治疗,治疗组在此基础上加用宋虎杰主任医师经验方解郁安神汤内服治疗 4 w.对比两组患者在治疗前后在 HAMD 量表、HAMA 量表、匹兹堡睡眠质量指数(PSQI)、简易精神状态检查量表(MMSE)、良性反应量表(TESS)、国家卫生研究院卒中量表(NIHSS)、ADL 评分量表上的表现.结果 对比两组患者在治疗前后的各项评分表分数,HAMD、HAMA、PSQI、NIHSS、TESS 这两组患者在治疗后的分数都有所降低,治疗组比对照组低;MMSE 评分,ADL 评分治疗组比对照组略高.两组差异具有统计学意义(P＞0.05).对比治疗前后两组患者各项评分量表得分情况,治疗后两组HAMD、HAMA、PSQI、NIHSS、TESS评分均降低,且治疗组低于对照组;MMSE评分、ADL评分治疗组略高于对照组.两组间差异有统计学意义(P<0.05).结论 宋虎杰主任医师经验方解郁安神汤对出血性死后抑郁患者的焦虑和抑郁状态有明显的改善作用,对提高日常生活能力、提高神经功能、提高夜间睡眠质量、无明显副作用,安全性更高.
Objective To investigate the clinical effect of Chief Physician Song Hujie's experience in the treatment of post-stroke depression and the improvement of quality of life and cognitive function.Methods A total of 32 patients with post-stroke depression admitted to Xi'an Hospital of Traditional Chinese Medicine Encephalopathy from January 2024 to De-cember 2024 were selected as the study subjects,and they were divided into treatment group and control group,with 16 ca-ses in each group.The control group was given conventional symptomatic treatment,and the treatment group was treated with the experience prescription of Chief Physician Song Hujie Jieyu Anshen decoction for 4 weeks.The HAMD scale,HAMA scale,Pittsburgh Sleep Quality Index(PSQI),Mini-Mental State Examination(MMSE),ADL Rating Scale,Ad-verse Reaction Scale(TESS)and NIHSS rating scale were compared between the two groups before and after treatment.Results The scores of HAMD,HAMA,PSQI,NIHSS,and TESS in the two groups were reduced after treatment,and the treatment group was lower than that of the control group.The MMSE score and ADL score in the treatment group were slightly higher than those in the control group.There was a statistically significant difference between the two groups(P<0.05).Conclusion Chief Physician Song Hujie's experience Fang Jieyu Anshen decoction can significantly improve the anxiety and depression of patients with post-hemorrhagic stroke depression,improve daily living ability,improve neurological function,and improve night sleep quality,without obvious side effects,and has higher safety.
王凌立;范小璇;薄晗;陈霄;刘燎原;王振国;张磊;宋虎杰
西安中医脑病医院,陕西 西安 712032陕西中医药大学,陕西 咸阳 712046西安中医脑病医院,陕西 西安 712032西安中医脑病医院,陕西 西安 712032西安中医脑病医院,陕西 西安 712032西安中医脑病医院,陕西 西安 712032西安中医脑病医院,陕西 西安 712032西安中医脑病医院,陕西 西安 712032
医药卫生
出血性卒中后抑郁解郁安神汤宋虎杰神经功能
post-hemorrhagic stroke depressionanti-depression and soothing soupSONG Hujieneurological function
《现代中医药》 2026 (2)
16-20,5
陕西省第三批优秀中医药人才研修项目陕西省高水平中医药重点学科建设项目(SXZYYZDXK20211008)宋虎杰全国名老中医专家传承工作室陕西省中医脑病临床医学研究中心建设项目(陕科社发[2017]176号)
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