温针灸治疗急性发作期溃疡性结肠炎的疗效观察及对肠道通透性和血清神经递质水平的影响OA

Objective To observe the clinical efficacy of warming needle in the treatment of ulcerative colitis(UC)in the acute active stage and its effects on intestinal permeability and serum neurotransmitter levels.Method One hundred patients with acute active UC were randomly divided into a control group and a study group,with 50 cases in each group.The control group received oral mesalazine enteric-coated tablets and compound Lactobacillus acidophilus tablets,while the study group received warming needle treatment based on the same regimen used in the control group.The Baron score and Geboes score before and after treatment were compared between the two groups.The levels of fecal α-1-antitrypsin(FAT)and fecal zonulin(FZ),as well as serum substance P(SP),vasoactive intestinal peptide(VIP),norepinephrine(NE),5-hydroxytryptamine(5-HT),acetylcholine,tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),and interleukin-17(IL-17),were compared before and after treatment.Clinical efficacy,recurrence rate,and adverse reactions of the two groups were also compared.Result The total effective rate was 72.0%in the control group and 92.0%in the study group,with a statistically significant difference between the two groups(P＜0.05).After treatment,the Baron score and Geboes score in the study group decreased and were lower than those in the control group(P＜0.05).The fecal FAT and FZ levels of both groups decreased after treatment(P＜0.05),and those in the study group were lower than those in the control group(P＜0.05).After treatment,the serum SP,5-HT,and NE levels of both groups decreased,and those in the study group were lower than those in the control group(P＜0.05).The serum acetylcholine and VIP levels increased in both groups,and those in the study group were higher than in the control group(P＜0.05).After treatment,the serum TNF-α,IL-6,and IL-17 levels in both groups decreased,and those in the study group were lower than in the control group(P＜0.05).The serum IL-10 levels increased in both groups,and those in the study group were higher than in the control group(P＜0.05).The recurrence rate was 26.0%in the control group and 10.0%in the study group(P＜0.05).The incidence of adverse reactions showed no statistically significant difference between the two groups(P＞0.05).Conclusion On the basis of oral mesalazine enteric-coated tablets and compound Lactobacillus acidophilus tablets,warming needle can effectively improve clinical efficacy in patients with acute active UC,ameliorate colonic mucosal lesions,reduce intestinal permeability,regulate neurotransmitter levels,and has good safety.