脐灸联合孟鲁司特钠治疗慢性阻塞性肺疾病急性加重的临床疗效及对血清PTX3和sICAM-1水平的影响OA
Clinical efficacy of umbilical moxibustion combined with montelukast sodium in the treatment of acute exacerbation of chronic obstructive pulmonary disease and its effects on serum PTX3 and sICAM-1 levels
目的 观察脐灸联合孟鲁司特钠治疗慢性阻塞性肺疾病急性加重(acute exacerbation of chronic obstructive pulmonary disease,AE-COPD)的临床疗效以及对血清正五聚蛋白3(pentraxin3,PTX3)和可溶性细胞间黏附因子(soluble intercellular adhesion molecule,sICAM)水平的影响.方法 将90例AE-COPD患者随机分为对照组和试验组,每组 45 例.两组均采用常规治疗,对照组予以孟鲁司特钠治疗,试验组在对照组基础上采用脐灸.观察两组治疗前后肺功能各项指标[1秒用力呼气容积(forced expiratory volume in one second,FEV1)、用力肺活量(forced vital capacity,FVC)以及呼气峰值流量(peak expiratory flow,PEF)]、血清PTX3和 sICAM 水平及改良呼吸困难指数(modified medical research council,mMRC)和 COPD 评估测试(COPD assessment test,CAT)评分变化,并比较两组临床疗效及不良反应发生情况.结果 两组治疗后血清 PTX3 和sICAM水平降低,且试验组低于对照组,差异有统计学意义(P＜0.05).两组治疗后mMRC和CAT评分降低,且试验组低于对照组,差异有统计学意义(P＜0.05).试验组总有效率为93.3%,对照组为 77.8%,试验组高于对照组(P＜0.05).试验组不良反应发生率为2.2%,低于对照组的 17.8%(P＜0.05).两组治疗后肺功能各项指标升高,且试验组高于对照组,差异有统计学意义(P＜0.05).结论 在常规治疗的基础上,脐灸联合孟鲁司特钠在提高AE-COPD患者肺功能、缓解呼吸困难、改善患者健康情况、降低炎症水平等方面优于单独使用孟鲁司特钠治疗,综合疗效显著,安全性高.
Objective To observe the clinical efficacy of umbilical moxibustion combined with montelukast sodium in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AE-COPD)and its effects on serum pentraxin 3(PTX3)and soluble intercellular adhesion molecule-1(sICAM-1)levels.Method Ninety AE-COPD patients were randomly divided into a control group and an experimental group,with 45 cases in each group.Both groups received conventional treatment;the control group was given montelukast sodium,while the experimental group received umbilical moxibustion in addition to the control treatment.Changes in pulmonary function indices[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and peak expiratory flow(PEF)],serum PTX3 and sICAM-1 levels,modified Medical Research Council(mMRC)dyspnea scale,and COPD assessment test(CAT)scores before and after treatment were observed.Clinical efficacy and the incidence of adverse reactions were compared between the two groups.Result After treatment,serum PTX3 and sICAM-1 levels decreased in both groups,and levels in the experimental group were lower than those in the control group(P＜0.05).mMRC and CAT scores decreased in both groups,with the experimental group scoring lower than the control group(P＜0.05).The total effective rate was 93.3%in the experimental group and 77.8%in the control group,with the experimental group being superior(P＜0.05).The incidence of adverse reactions was 2.2%in the experimental group,lower than 17.8%in the control group(P＜0.05).Pulmonary function indices increased in both groups after treatment,with higher values in the experimental group than in the control group(P＜0.05).Conclusion On the basis of conventional treatment,umbilical moxibustion combined with montelukast sodium is superior to montelukast sodium alone in improving pulmonary function,relieving dyspnea,enhancing patient health status,and reducing inflammation levels in AE-COPD patients.It demonstrates significant comprehensive efficacy and high safety.
杨纯;李奕翰;陈晓枫
成都市金牛区中医院,成都 610083成都市金牛区中医院,成都 610083四川省第二中医医院,成都 610031
医药卫生
肺疾病,慢性阻塞性隔药脐灸孟鲁司特钠肺功能气虚
Chronic obstructive pulmonary diseaseMoxibustionHerb-partition umbilical moxibustionMontelukast sodiumPulmonary functionQi deficiency
《上海针灸杂志》 2026 (3)
260-265,6
四川省卫生健康委员会医学科技项目(21ZD010)
评论