Nrf2/NF-κB通路及低氧环境下探讨动物氧化应激的研究进展OA
Nrf2/NF-κB Pathway and Low Oxygen Environment to Explore Progress of Oxidative Stress in Animals
氧是机体生命活动不可或缺的元素之一,低氧等因素可释放自由基,导致机体活性氧(reactive oxygen species,ROS)增加,从而使细胞膜脂质代谢失调并破坏正常的氧代谢平衡.在低氧条件下,机体会产生一种非特异性反应,即氧化应激(oxidative stress,OS),氧化应激会使机体的内环境稳态失衡,最终引起局部或全身的变化.核因子E2相关因子2(Nrf2)/核因子κB(NF-κB)是参与动物氧化应激的重要信号通路,其活性的激活和抑制在动物氧化应激进展中起到了至关重要的作用.文章对Nrf2/NF-κB通路在动物氧化应激的作用机制以及在低氧环境下适应性通过干预该通路缓解动物在生产中氧化应激的研究进展进行简要综述,为减少应激损伤的研究提供理论依据.
Oxygen is one of the indispensable elements of the body's life activities.Hypoxia and other fac-tors can induce the increase of reactive oxygen species(ROS)and free radical release in the body,thus breaking the normal oxygen metabolism balance and causing the disorder of lipid metabolism in cell mem-brane.Under hypoxia conditions,the body will produce a non-specific reaction,that is,oxidative stress(OS),which will make the homeostasis of the body unbalanced and eventually lead to local or systemic changes.Nrf2/NF-κB is an important signaling pathway involved in oxidative stress in animals,and the acti-vation and inhibition of its activity play a crucial role in the progression of oxidative stress in animals.There-fore,the mechanism of Nrf2/NF-κB pathway on oxidative stress in animals and the research progress of alle-viating oxidative stress in animals during production and adaptation under yhpoxic environments,which will provide a theoretical basis for future research on reducing stress damage.
许恩榕;吴华;陈林;郑润韬;王文胜;刘嘉逸;陈自鑫
青海大学农牧学院,青海 西宁 810016青海大学农牧学院,青海 西宁 810016青海大学农牧学院,青海 西宁 810016青海大学农牧学院,青海 西宁 810016青海大学农牧学院,青海 西宁 810016青海大学农牧学院,青海 西宁 810016青海大学农牧学院,青海 西宁 810016
农业科技
氧化应激Nrf2通路NF-κB通路低氧适应性炎症损伤
oxidative stressNrf2 pathwayNF-κB pathwayhypoxic adaptationinflammatory damage
《饲料工业》 2026 (6)
34-42,9
国家自然科学基金项目[3216200263]
评论